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000004373 0247_ $$2DOI$$a10.1113/jphysiol.2009.169458
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000004373 084__ $$2WoS$$aNeurosciences
000004373 084__ $$2WoS$$aPhysiology
000004373 1001_ $$0P:(DE-Juel1)131680$$aFeldmeyer, D.$$b0$$uFZJ
000004373 245__ $$aDevelopmental alterations in the functional properties of excitatory neocortical synapses
000004373 260__ $$a[S.l.]$$bWiley-Blackwell$$c2009
000004373 300__ $$a1889 - 1896
000004373 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
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000004373 440_0 $$06411$$aThe Journal of Physiology$$v587$$x0022-3751$$y9
000004373 500__ $$aThis work was supported in part by the Helmholtz Society and a grant from the Deutsche Forschungsgemeinschaft (FE471/2-1) to D.F.
000004373 520__ $$aIn the neocortex, most excitatory, glutamatergic synapses are established during the first 4-5 weeks after birth. During this period profound changes in the properties of synaptic transmission occur. Excitatory postsynaptic potentials (EPSPs) at immature synaptic connections are profoundly and progressively reduced in response to moderate to high frequency (5-100 Hz) stimulation. With maturation, this frequency-dependent depression becomes progressively weaker and may eventually transform into a weak to moderate EPSP facilitation. In parallel to changes in the short-term plasticity, a reduction in the synaptic reliability occurs at most glutamatergic neocortical synapses: immature synapses show a high probability of neurotransmitter release as indicated by their low failure rate and small EPSP amplitude variation. This high reliability is reduced in mature synapses, which show considerably higher failure rates and more variable EPSP amplitudes. During early neocortical development synaptic vesicle pools are not yet fully differentiated and their replenishment may be slow, thus resulting in EPSP amplitude depression. The decrease in the probability of neurotransmitter release may be the result of an altered Ca(2+) control in the presynaptic terminal with a reduced Ca(2+) influx and/or a higher Ca(2+) buffering capacity. This may lead to a lower synaptic reliability and a weaker short-term synaptic depression with maturation.
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000004373 650_2 $$2MeSH$$aAdaptation, Physiological: physiology
000004373 650_2 $$2MeSH$$aAnimals
000004373 650_2 $$2MeSH$$aExcitatory Postsynaptic Potentials: physiology
000004373 650_2 $$2MeSH$$aHumans
000004373 650_2 $$2MeSH$$aModels, Neurological
000004373 650_2 $$2MeSH$$aNeocortex: embryology
000004373 650_2 $$2MeSH$$aNeocortex: physiology
000004373 650_2 $$2MeSH$$aNerve Net: physiology
000004373 650_2 $$2MeSH$$aSynapses: physiology
000004373 650_2 $$2MeSH$$aSynaptic Transmission: physiology
000004373 650_7 $$2WoSType$$aJ
000004373 7001_ $$0P:(DE-Juel1)VDB36676$$aRadnikow, G.$$b1$$uFZJ
000004373 773__ $$0PERI:(DE-600)1475290-6$$a10.1113/jphysiol.2009.169458$$gVol. 587, p. 1889 - 1896$$p1889 - 1896$$q587<1889 - 1896$$tThe @journal of physiology$$v587$$x0022-3751$$y2009
000004373 8567_ $$2Pubmed Central$$uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2689330
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