TY  - JOUR
AU  - Feldmeyer, D.
AU  - Radnikow, G.
TI  - Developmental alterations in the functional properties of excitatory neocortical synapses
JO  - The journal of physiology
VL  - 587
SN  - 0022-3751
CY  - [S.l.]
PB  - Wiley-Blackwell
M1  - PreJuSER-4373
SP  - 1889 - 1896
PY  - 2009
N1  - This work was supported in part by the Helmholtz Society and a grant from the Deutsche Forschungsgemeinschaft (FE471/2-1) to D.F.
AB  - In the neocortex, most excitatory, glutamatergic synapses are established during the first 4-5 weeks after birth. During this period profound changes in the properties of synaptic transmission occur. Excitatory postsynaptic potentials (EPSPs) at immature synaptic connections are profoundly and progressively reduced in response to moderate to high frequency (5-100 Hz) stimulation. With maturation, this frequency-dependent depression becomes progressively weaker and may eventually transform into a weak to moderate EPSP facilitation. In parallel to changes in the short-term plasticity, a reduction in the synaptic reliability occurs at most glutamatergic neocortical synapses: immature synapses show a high probability of neurotransmitter release as indicated by their low failure rate and small EPSP amplitude variation. This high reliability is reduced in mature synapses, which show considerably higher failure rates and more variable EPSP amplitudes. During early neocortical development synaptic vesicle pools are not yet fully differentiated and their replenishment may be slow, thus resulting in EPSP amplitude depression. The decrease in the probability of neurotransmitter release may be the result of an altered Ca(2+) control in the presynaptic terminal with a reduced Ca(2+) influx and/or a higher Ca(2+) buffering capacity. This may lead to a lower synaptic reliability and a weaker short-term synaptic depression with maturation.
KW  - Adaptation, Physiological: physiology
KW  - Animals
KW  - Excitatory Postsynaptic Potentials: physiology
KW  - Humans
KW  - Models, Neurological
KW  - Neocortex: embryology
KW  - Neocortex: physiology
KW  - Nerve Net: physiology
KW  - Synapses: physiology
KW  - Synaptic Transmission: physiology
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
C6  - pmid:19273572
C2  - pmc:PMC2689330
UR  - <Go to ISI:>//WOS:000265617000008
DO  - DOI:10.1113/jphysiol.2009.169458
UR  - https://juser.fz-juelich.de/record/4373
ER  -