% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Feldmeyer:4373,
      author       = {Feldmeyer, D. and Radnikow, G.},
      title        = {{D}evelopmental alterations in the functional properties of
                      excitatory neocortical synapses},
      journal      = {The journal of physiology},
      volume       = {587},
      issn         = {0022-3751},
      address      = {[S.l.]},
      publisher    = {Wiley-Blackwell},
      reportid     = {PreJuSER-4373},
      pages        = {1889 - 1896},
      year         = {2009},
      note         = {This work was supported in part by the Helmholtz Society
                      and a grant from the Deutsche Forschungsgemeinschaft
                      (FE471/2-1) to D.F.},
      abstract     = {In the neocortex, most excitatory, glutamatergic synapses
                      are established during the first 4-5 weeks after birth.
                      During this period profound changes in the properties of
                      synaptic transmission occur. Excitatory postsynaptic
                      potentials (EPSPs) at immature synaptic connections are
                      profoundly and progressively reduced in response to moderate
                      to high frequency (5-100 Hz) stimulation. With maturation,
                      this frequency-dependent depression becomes progressively
                      weaker and may eventually transform into a weak to moderate
                      EPSP facilitation. In parallel to changes in the short-term
                      plasticity, a reduction in the synaptic reliability occurs
                      at most glutamatergic neocortical synapses: immature
                      synapses show a high probability of neurotransmitter release
                      as indicated by their low failure rate and small EPSP
                      amplitude variation. This high reliability is reduced in
                      mature synapses, which show considerably higher failure
                      rates and more variable EPSP amplitudes. During early
                      neocortical development synaptic vesicle pools are not yet
                      fully differentiated and their replenishment may be slow,
                      thus resulting in EPSP amplitude depression. The decrease in
                      the probability of neurotransmitter release may be the
                      result of an altered Ca(2+) control in the presynaptic
                      terminal with a reduced Ca(2+) influx and/or a higher Ca(2+)
                      buffering capacity. This may lead to a lower synaptic
                      reliability and a weaker short-term synaptic depression with
                      maturation.},
      keywords     = {Adaptation, Physiological: physiology / Animals /
                      Excitatory Postsynaptic Potentials: physiology / Humans /
                      Models, Neurological / Neocortex: embryology / Neocortex:
                      physiology / Nerve Net: physiology / Synapses: physiology /
                      Synaptic Transmission: physiology / J (WoSType)},
      cin          = {INM-2 / JARA-BRAIN},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-2-20090406 / $I:(DE-82)080010_20140620$},
      pnm          = {Funktion und Dysfunktion des Nervensystems},
      pid          = {G:(DE-Juel1)FUEK409},
      shelfmark    = {Neurosciences / Physiology},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:19273572},
      pmc          = {pmc:PMC2689330},
      UT           = {WOS:000265617000008},
      doi          = {10.1113/jphysiol.2009.169458},
      url          = {https://juser.fz-juelich.de/record/4373},
}