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000004420 0247_ $$2DOI$$a10.1098/rsta.2008.0287
000004420 0247_ $$2WOS$$aWOS:000265731600015
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000004420 041__ $$aeng
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000004420 084__ $$2WoS$$aMultidisciplinary Sciences
000004420 1001_ $$0P:(DE-Juel1)131678$$aEickhoff, S. B.$$b0$$uFZJ
000004420 245__ $$aA systems perspective on the effective connectivity of overt speech production
000004420 260__ $$aLondon$$bSoc.$$c2009
000004420 300__ $$a2399 - 2421
000004420 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
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000004420 440_0 $$04892$$aPhilosophical Transactions of the Royal Society of London Series A$$v367$$x1364-503X$$y1896
000004420 500__ $$aThis Human Brain Project/Neuroinformatics research was funded by the National Institute of Biomedical Imaging and Bioengineering, the National Institute of Neurological Disorders and Stroke and the National Institute of Mental Health. Further funding was provided by the DFG (KFO-112; to K.Z.), the BMBF (01GW0771; to K.A.), the Human Brain Project (R01-MH074457-01A1; to S.B.E.) and the Helmholz Initiative on Systems-Biology (to K.Z. and S. B.E.).
000004420 520__ $$aThe aim of this study was to provide a computational system model of effective connectivity in the human brain underlying overt speech production. Meta-analysis of neuroimaging studies and functional magnetic resonance imaging data acquired during a verbal fluency task revealed a core network consisting of Brodmann's area (BA) 44 in Broca's region, anterior insula, basal ganglia, cerebellum, premotor cortex (PMC, BA 6) and primary motor cortex (M1, areas 4a/4p). Dynamic causal modelling (DCM) indicated the highest evidence for a system architecture featuring the insula in a serial position between BA 44 and two parallel nodes (cerebellum/basal ganglia), from which information converges onto the PMC and finally M1. Parameter inference revealed that effective connectivity from the insular relay into the cerebellum/basal ganglia is primarily task driven (preparation) while the output into the cortical motor system strongly depends on the actual word production rate (execution). DCM hence allowed not only a quantitative characterization of the human speech production network, but also the distinction of a preparatory and an executive subsystem within it. The proposed model of physiological integration during speech production may now serve as a reference for investigations into the neurobiology of pathological states such as dysarthria and apraxia of speech.
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000004420 65320 $$2Author$$aspeech
000004420 65320 $$2Author$$adynamic causal modelling
000004420 65320 $$2Author$$ameta-analysis
000004420 65320 $$2Author$$afunctional magnetic resonance imaging
000004420 65320 $$2Author$$aconnectivity
000004420 65320 $$2Author$$amotor
000004420 650_2 $$2MeSH$$aHumans
000004420 650_2 $$2MeSH$$aMagnetic Resonance Imaging
000004420 650_2 $$2MeSH$$aModels, Biological
000004420 650_2 $$2MeSH$$aSpeech
000004420 650_2 $$2MeSH$$aSystems Biology
000004420 650_7 $$2WoSType$$aJ
000004420 7001_ $$0P:(DE-Juel1)VDB33807$$aHeim, S.$$b1$$uFZJ
000004420 7001_ $$0P:(DE-Juel1)131714$$aZilles, K.$$b2$$uFZJ
000004420 7001_ $$0P:(DE-Juel1)131631$$aAmunts, K.$$b3$$uFZJ
000004420 773__ $$0PERI:(DE-600)1462626-3$$a10.1098/rsta.2008.0287$$gVol. 367, p. 2399 - 2421$$p2399 - 2421$$q367<2399 - 2421$$tPhilosophical transactions of the Royal Society of London / A$$v367$$x1364-503X$$y2009
000004420 8567_ $$2Pubmed Central$$uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268212
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