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@ARTICLE{Eickhoff:4420,
      author       = {Eickhoff, S. B. and Heim, S. and Zilles, K. and Amunts, K.},
      title        = {{A} systems perspective on the effective connectivity of
                      overt speech production},
      journal      = {Philosophical transactions of the Royal Society of London /
                      A},
      volume       = {367},
      issn         = {1364-503X},
      address      = {London},
      publisher    = {Soc.},
      reportid     = {PreJuSER-4420},
      pages        = {2399 - 2421},
      year         = {2009},
      note         = {This Human Brain Project/Neuroinformatics research was
                      funded by the National Institute of Biomedical Imaging and
                      Bioengineering, the National Institute of Neurological
                      Disorders and Stroke and the National Institute of Mental
                      Health. Further funding was provided by the DFG (KFO-112; to
                      K.Z.), the BMBF (01GW0771; to K.A.), the Human Brain Project
                      (R01-MH074457-01A1; to S.B.E.) and the Helmholz Initiative
                      on Systems-Biology (to K.Z. and S. B.E.).},
      abstract     = {The aim of this study was to provide a computational system
                      model of effective connectivity in the human brain
                      underlying overt speech production. Meta-analysis of
                      neuroimaging studies and functional magnetic resonance
                      imaging data acquired during a verbal fluency task revealed
                      a core network consisting of Brodmann's area (BA) 44 in
                      Broca's region, anterior insula, basal ganglia, cerebellum,
                      premotor cortex (PMC, BA 6) and primary motor cortex (M1,
                      areas 4a/4p). Dynamic causal modelling (DCM) indicated the
                      highest evidence for a system architecture featuring the
                      insula in a serial position between BA 44 and two parallel
                      nodes (cerebellum/basal ganglia), from which information
                      converges onto the PMC and finally M1. Parameter inference
                      revealed that effective connectivity from the insular relay
                      into the cerebellum/basal ganglia is primarily task driven
                      (preparation) while the output into the cortical motor
                      system strongly depends on the actual word production rate
                      (execution). DCM hence allowed not only a quantitative
                      characterization of the human speech production network, but
                      also the distinction of a preparatory and an executive
                      subsystem within it. The proposed model of physiological
                      integration during speech production may now serve as a
                      reference for investigations into the neurobiology of
                      pathological states such as dysarthria and apraxia of
                      speech.},
      keywords     = {Humans / Magnetic Resonance Imaging / Models, Biological /
                      Speech / Systems Biology / J (WoSType)},
      cin          = {INM-2 / INM-1 / JARA-BRAIN},
      ddc          = {530},
      cid          = {I:(DE-Juel1)INM-2-20090406 / I:(DE-Juel1)INM-1-20090406 /
                      $I:(DE-82)080010_20140620$},
      pnm          = {Funktion und Dysfunktion des Nervensystems},
      pid          = {G:(DE-Juel1)FUEK409},
      shelfmark    = {Multidisciplinary Sciences},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:19414462},
      pmc          = {pmc:PMC3268212},
      UT           = {WOS:000265731600015},
      doi          = {10.1098/rsta.2008.0287},
      url          = {https://juser.fz-juelich.de/record/4420},
}