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@ARTICLE{Steffen:44369,
author = {Steffen, B. and Müller, K. P. and Komenda, M. and
Koppmann, R. and Schaub, A.},
title = {{A} new mathematical procedure to evaluate peaks in complex
chromatograms},
journal = {Journal of chromatography / A},
volume = {1071},
issn = {0021-9673},
address = {New York, NY [u.a.]},
publisher = {Science Direct},
reportid = {PreJuSER-44369},
year = {2005},
note = {Record converted from VDB: 12.11.2012},
abstract = {Automatic peak evaluation in chromatograms and subsequent
quantification of compound concentrations is still a
challenge in the analysis of complex samples containing
hundreds or thousands of compounds. Although a number of
software packages for peak evaluation exist, baseline
definition and overlapping peaks of different shapes are the
main reasons which prevent reliable automatic analysis of
complex chromatograms. A new mathematical procedure is
presented which uses peak shapes extracted from the
chromatogram itself and modified by nonlinear (in fact,
hyperbolic) stretching of the peak head and tail. With this
approach, the peak parameters are position, height, scale of
front, scale of tail, and smoothness of transition from
front to tail scaling. This approach is found to give a
substantially better fit than traditional analytically
defined peak shapes. Together with a good peak finding
heuristic and nonlinear optimization of parameters this
allows a reliable automatic analysis of chromatograms with a
large number of peaks, even with large groups of overlapping
peaks. The analysis matches the quality of standard
interactive methods, but still permits interactive
refinement. This approach has been implemented and tested on
a large set of data from chromatography of hydrocarbons in
ambient air samples. (c) 2004 Elsevier B.V. All rights
reserved.},
keywords = {J (WoSType)},
cin = {ICG-II / ZAM},
ddc = {540},
cid = {I:(DE-Juel1)VDB48 / I:(DE-Juel1)VDB62},
pnm = {Chemie und Dynamik der Geo-Biosphäre},
pid = {G:(DE-Juel1)FUEK257},
shelfmark = {Biochemical Research Methods / Chemistry, Analytical},
typ = {PUB:(DE-HGF)16},
UT = {WOS:000228401300034},
pubmed = {pmid:15865199},
doi = {10.1016/j.chroma.2004.11.073},
url = {https://juser.fz-juelich.de/record/44369},
}