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000045088 0247_ $$2DOI$$a10.1523/JNEUROSCI.5227-04.2005
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000045088 084__ $$2WoS$$aNeurosciences
000045088 1001_ $$0P:(DE-Juel1)131680$$aFeldmeyer, D.$$b0$$uFZJ
000045088 245__ $$aMonosynaptic connections between pairs of spiny stellate cells in layer 4 and pyramidal cells in layer 5a indicate that lemniscal and paralemniscal afferent pathways converge in the infragranular somatosensory cortex
000045088 260__ $$aWashington, DC$$bSoc.$$c2005
000045088 300__ $$a3431 - 3423
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000045088 440_0 $$03603$$aJournal of Neuroscience$$v25$$x0270-6474$$y13
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000045088 520__ $$aMonosynaptic interlaminar connections between spiny stellate cells in layer 4 (L4), the main cortical recipient layer for thalamic projections, and pyramidal cells in layer 5A (L5A), one of the main cortical output layers, were examined anatomically and functionally by paired recordings in acute brain slices. The somata of pairs forming interlaminar L4-to-L5A connections were located predominantly close to or directly under the barrel-septum wall in layer 4. Superposition of spiny stellate axon arbors and L5A pyramidal cell dendritic arbors suggested an innervation domain underneath an L4 barrel wall. Functionally, the L4-to-L5A connections were of high reliability and relatively low efficacy, with a unitary EPSP amplitude of 0.6 mV, and the connectivity was moderately high (one in seven pairs tested was connected). The EPSP amplitude was weakly depressing (paired-pulse ratio of approximately 0.8) during repetitive presynaptic action potentials at 10 Hz. The existence of monosynaptic L4-to-L5A connections indicates that the specific "lemniscal" thalamic input from the ventro-basal nucleus of the thalamus to the cortex and the more unspecific "paralemniscal" afferent thalamic projections from the posterior medial nucleus of the thalamus merge already at an initial stage of cortical signal processing. These monosynaptic connections establish a monosynaptic coupling of the input to the cortex and its output, thereby effectively bypassing the supragranular layers.
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000045088 650_2 $$2MeSH$$aAfferent Pathways: cytology
000045088 650_2 $$2MeSH$$aAfferent Pathways: physiology
000045088 650_2 $$2MeSH$$aAnimals
000045088 650_2 $$2MeSH$$aElectric Stimulation: methods
000045088 650_2 $$2MeSH$$aExcitatory Postsynaptic Potentials: physiology
000045088 650_2 $$2MeSH$$aExcitatory Postsynaptic Potentials: radiation effects
000045088 650_2 $$2MeSH$$aImage Processing, Computer-Assisted: methods
000045088 650_2 $$2MeSH$$aLysine: analogs & derivatives
000045088 650_2 $$2MeSH$$aLysine: metabolism
000045088 650_2 $$2MeSH$$aNeural Networks (Computer)
000045088 650_2 $$2MeSH$$aNeurons: classification
000045088 650_2 $$2MeSH$$aNeurons: cytology
000045088 650_2 $$2MeSH$$aNeurons: physiology
000045088 650_2 $$2MeSH$$aPatch-Clamp Techniques: methods
000045088 650_2 $$2MeSH$$aRats
000045088 650_2 $$2MeSH$$aRats, Wistar
000045088 650_2 $$2MeSH$$aReaction Time: physiology
000045088 650_2 $$2MeSH$$aReaction Time: radiation effects
000045088 650_2 $$2MeSH$$aSomatosensory Cortex: cytology
000045088 650_2 $$2MeSH$$aSynapses: physiology
000045088 650_7 $$056-87-1$$2NLM Chemicals$$aLysine
000045088 650_7 $$0576-19-2$$2NLM Chemicals$$abiocytin
000045088 650_7 $$2WoSType$$aJ
000045088 65320 $$2Author$$abarrel cortex
000045088 65320 $$2Author$$asynaptic transmission
000045088 65320 $$2Author$$alayer 4
000045088 65320 $$2Author$$alayer 5A
000045088 65320 $$2Author$$acortical microcircuits
000045088 65320 $$2Author$$apyramidal cell
000045088 7001_ $$0P:(DE-HGF)0$$aRoth, A.$$b1
000045088 7001_ $$0P:(DE-HGF)0$$aSakmann, B.$$b2
000045088 773__ $$0PERI:(DE-600)1475274-8$$a10.1523/JNEUROSCI.5227-04.2005$$gVol. 25, p. 3431 - 3423$$p3431 - 3423$$q25<3431 - 3423$$tThe @journal of neuroscience$$v25$$x0270-6474$$y2005
000045088 8567_ $$uhttp://dx.doi.org/10.1523/JNEUROSCI.5227-04.2005
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