TY  - JOUR
AU  - Feldmeyer, D.
AU  - Roth, A.
AU  - Sakmann, B.
TI  - Monosynaptic connections between pairs of spiny stellate cells in layer 4 and pyramidal cells in layer 5a indicate that lemniscal and paralemniscal afferent pathways converge in the infragranular somatosensory cortex
JO  - The journal of neuroscience
VL  - 25
SN  - 0270-6474
CY  - Washington, DC
PB  - Soc.
M1  - PreJuSER-45088
SP  - 3431 - 3423
PY  - 2005
N1  - Record converted from VDB: 12.11.2012
AB  - Monosynaptic interlaminar connections between spiny stellate cells in layer 4 (L4), the main cortical recipient layer for thalamic projections, and pyramidal cells in layer 5A (L5A), one of the main cortical output layers, were examined anatomically and functionally by paired recordings in acute brain slices. The somata of pairs forming interlaminar L4-to-L5A connections were located predominantly close to or directly under the barrel-septum wall in layer 4. Superposition of spiny stellate axon arbors and L5A pyramidal cell dendritic arbors suggested an innervation domain underneath an L4 barrel wall. Functionally, the L4-to-L5A connections were of high reliability and relatively low efficacy, with a unitary EPSP amplitude of 0.6 mV, and the connectivity was moderately high (one in seven pairs tested was connected). The EPSP amplitude was weakly depressing (paired-pulse ratio of approximately 0.8) during repetitive presynaptic action potentials at 10 Hz. The existence of monosynaptic L4-to-L5A connections indicates that the specific "lemniscal" thalamic input from the ventro-basal nucleus of the thalamus to the cortex and the more unspecific "paralemniscal" afferent thalamic projections from the posterior medial nucleus of the thalamus merge already at an initial stage of cortical signal processing. These monosynaptic connections establish a monosynaptic coupling of the input to the cortex and its output, thereby effectively bypassing the supragranular layers.
KW  - Afferent Pathways: cytology
KW  - Afferent Pathways: physiology
KW  - Animals
KW  - Electric Stimulation: methods
KW  - Excitatory Postsynaptic Potentials: physiology
KW  - Excitatory Postsynaptic Potentials: radiation effects
KW  - Image Processing, Computer-Assisted: methods
KW  - Lysine: analogs & derivatives
KW  - Lysine: metabolism
KW  - Neural Networks (Computer)
KW  - Neurons: classification
KW  - Neurons: cytology
KW  - Neurons: physiology
KW  - Patch-Clamp Techniques: methods
KW  - Rats
KW  - Rats, Wistar
KW  - Reaction Time: physiology
KW  - Reaction Time: radiation effects
KW  - Somatosensory Cortex: cytology
KW  - Synapses: physiology
KW  - Lysine (NLM Chemicals)
KW  - biocytin (NLM Chemicals)
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
C6  - pmid:15800197
UR  - <Go to ISI:>//WOS:000228038200019
DO  - DOI:10.1523/JNEUROSCI.5227-04.2005
UR  - https://juser.fz-juelich.de/record/45088
ER  -