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@ARTICLE{Feldmeyer:45088,
      author       = {Feldmeyer, D. and Roth, A. and Sakmann, B.},
      title        = {{M}onosynaptic connections between pairs of spiny stellate
                      cells in layer 4 and pyramidal cells in layer 5a indicate
                      that lemniscal and paralemniscal afferent pathways converge
                      in the infragranular somatosensory cortex},
      journal      = {The journal of neuroscience},
      volume       = {25},
      issn         = {0270-6474},
      address      = {Washington, DC},
      publisher    = {Soc.},
      reportid     = {PreJuSER-45088},
      pages        = {3431 - 3423},
      year         = {2005},
      note         = {Record converted from VDB: 12.11.2012},
      abstract     = {Monosynaptic interlaminar connections between spiny
                      stellate cells in layer 4 (L4), the main cortical recipient
                      layer for thalamic projections, and pyramidal cells in layer
                      5A (L5A), one of the main cortical output layers, were
                      examined anatomically and functionally by paired recordings
                      in acute brain slices. The somata of pairs forming
                      interlaminar L4-to-L5A connections were located
                      predominantly close to or directly under the barrel-septum
                      wall in layer 4. Superposition of spiny stellate axon arbors
                      and L5A pyramidal cell dendritic arbors suggested an
                      innervation domain underneath an L4 barrel wall.
                      Functionally, the L4-to-L5A connections were of high
                      reliability and relatively low efficacy, with a unitary EPSP
                      amplitude of 0.6 mV, and the connectivity was moderately
                      high (one in seven pairs tested was connected). The EPSP
                      amplitude was weakly depressing (paired-pulse ratio of
                      approximately 0.8) during repetitive presynaptic action
                      potentials at 10 Hz. The existence of monosynaptic L4-to-L5A
                      connections indicates that the specific "lemniscal" thalamic
                      input from the ventro-basal nucleus of the thalamus to the
                      cortex and the more unspecific "paralemniscal" afferent
                      thalamic projections from the posterior medial nucleus of
                      the thalamus merge already at an initial stage of cortical
                      signal processing. These monosynaptic connections establish
                      a monosynaptic coupling of the input to the cortex and its
                      output, thereby effectively bypassing the supragranular
                      layers.},
      keywords     = {Afferent Pathways: cytology / Afferent Pathways: physiology
                      / Animals / Electric Stimulation: methods / Excitatory
                      Postsynaptic Potentials: physiology / Excitatory
                      Postsynaptic Potentials: radiation effects / Image
                      Processing, Computer-Assisted: methods / Lysine: analogs
                      $\&$ derivatives / Lysine: metabolism / Neural Networks
                      (Computer) / Neurons: classification / Neurons: cytology /
                      Neurons: physiology / Patch-Clamp Techniques: methods / Rats
                      / Rats, Wistar / Reaction Time: physiology / Reaction Time:
                      radiation effects / Somatosensory Cortex: cytology /
                      Synapses: physiology / Lysine (NLM Chemicals) / biocytin
                      (NLM Chemicals) / J (WoSType)},
      cin          = {IME},
      ddc          = {590},
      cid          = {I:(DE-Juel1)VDB54},
      pnm          = {Neurowissenschaften},
      pid          = {G:(DE-Juel1)FUEK255},
      shelfmark    = {Neurosciences},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:15800197},
      UT           = {WOS:000228038200019},
      doi          = {10.1523/JNEUROSCI.5227-04.2005},
      url          = {https://juser.fz-juelich.de/record/45088},
}