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000004525 084__ $$2WoS$$aClinical Neurology
000004525 084__ $$2WoS$$aNeurosciences
000004525 1001_ $$0P:(DE-Juel1)VDB65869$$aFunke, S. A.$$b0$$uFZJ
000004525 245__ $$aDetection of Amyloid-ß aggregates in body fluids: A suitable method for early diagnosis of Alzheimer's disease?
000004525 260__ $$aHilversum$$bBentham Science Publishers Ltd.$$c2009
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000004525 440_0 $$020682$$aCurrent Alzheimer Research$$v6$$x1567-2050$$y3
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000004525 520__ $$aToday, the most reliable diagnosis for Alzheimer's disease (AD) is the post mortem identification of amyloid plaques, consisting of the Amyloid-beta (A beta) peptide, (and neurofibrillary tangles) in the brain of the patient. Great efforts are being made to identify reliable biomarkers for AD that are suitable for minimal invasive early diagnosis and prognosis of AD. During the past years, body fluids of AD patients were assayed for their content of total or soluble A beta (1-40) or A beta (1-42) concentrations using classical (ELISA) or non-classical (with additional signal amplification) read-out. Cerebrospinal fluid (CSF) concentrations of soluble A beta (1-42) are reduced by 40 to 50 % in AD patients compared to age-matched healthy controls as confirmed in more than 30 studies, with both sensitivity and specificity exceeding 80 % in most of the studies. Thus, it was suggested that low levels of CSF A beta (1-42) might be useful for preclinical diagnosis. Because the current average sensitivity of AD biomarker detection in the CSF is approximately 85 %, these assays do not offer a considerable increase in predictive value over existing algorithms based on neuropsychological and imaging modalities. Regarding the amyloid cascade hypothesis, A beta oligomers and aggregates are directly involved in the pathogenic process. Therefore, presence of A beta aggregates seem to be the most direct disease biomarker for AD and increasing effort is being made into the development of methods suitable for the detection of different A beta aggregates in body fluids like CSF and plasma. We therefore give an overview of the current state of A beta aggregate specific detection.
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000004525 65320 $$2Author$$aAlzheimer's disease
000004525 65320 $$2Author$$aearly-diagnosis
000004525 65320 $$2Author$$aprognosis
000004525 65320 $$2Author$$atherapy monitoring
000004525 65320 $$2Author$$aAmyloid-beta aggregates
000004525 65320 $$2Author$$aprotein misfolding diseases
000004525 65320 $$2Author$$abiomarker
000004525 7001_ $$0P:(DE-Juel1)VDB65870$$aBirkmann, E.$$b1$$uFZJ
000004525 7001_ $$0P:(DE-Juel1)132029$$aWillbold, D.$$b2$$uFZJ
000004525 773__ $$0PERI:(DE-600)2155964-8$$gVol. 6, p. 285 - 289$$p285 - 289$$q6<285 - 289$$tCurrent Alzheimer research$$v6$$x1567-2050$$y2009
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