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@ARTICLE{Hinds:4533,
author = {Hinds, O. and Polimeni, J.R. and Rajendran, N. and
Balasubramanian, M. and Amunts, K. and Zilles, K. and
Schwartz, E.L. and Fischl, B. and Triantafyllou, C.},
title = {{L}ocating the functional and anatomical boundaries of
human primary visual cortex},
journal = {NeuroImage},
volume = {46},
issn = {1053-8119},
address = {Orlando, Fla.},
publisher = {Academic Press},
reportid = {PreJuSER-4533},
pages = {915 - 922},
year = {2009},
note = {Record converted from VDB: 12.11.2012},
abstract = {The primary visual cortex (V1) can be delineated both
functionally by its topographic map of the visual field and
anatomically by its distinct pattern of laminar myelination.
Although it is commonly assumed that the specialized anatomy
V1 exhibits corresponds in location with functionally
defined V1, demonstrating this in human has not been
possible thus far due to the difficulty of determining the
location of V1 both functionally and anatomically in the
same individual. In this study we use MRI to measure the
anatomical and functional V1 boundaries in the same
individual and demonstrate close agreement between them.
Functional V1 location was measured by parcellating
occipital cortex of 10 living humans into visual cortical
areas based on the topographic map of the visual field
measured using functional MRI. Anatomical V1 location was
estimated for these same subjects using a surface-based
probabilistic atlas derived from high-resolution structural
MRI of the stria of Gennari in 10 intact ex vivo human
hemispheres. To ensure that the atlas prediction was
correct, it was validated against V1 location measured using
an observer-independent cortical parcellation based on the
laminar pattern of cell density in serial brain sections
from 10 separate individuals. The close agreement between
the independent anatomically and functionally derived V1
boundaries indicates that the whole extent of V1 can be
accurately predicted based on cortical surface
reconstructions computed from structural MRI scans,
eliminating the need for functional localizers of V1. In
addition, that the primary cortical folds predict the
location of functional V1 suggests that the mechanism giving
rise to V1 location is tied to the development of the
cortical folds.},
keywords = {Brain Mapping: methods / Humans / Image Interpretation,
Computer-Assisted / Magnetic Resonance Imaging / Visual
Cortex: anatomy $\&$ histology / J (WoSType)},
cin = {INM-1 / INM-2 / JARA-BRAIN},
ddc = {610},
cid = {I:(DE-Juel1)INM-1-20090406 / I:(DE-Juel1)INM-2-20090406 /
$I:(DE-82)080010_20140620$},
pnm = {Funktion und Dysfunktion des Nervensystems},
pid = {G:(DE-Juel1)FUEK409},
shelfmark = {Neurosciences / Neuroimaging / Radiology, Nuclear Medicine
$\&$ Medical Imaging},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:19328238},
pmc = {pmc:PMC2712139},
UT = {WOS:000266975600005},
doi = {10.1016/j.neuroimage.2009.03.036},
url = {https://juser.fz-juelich.de/record/4533},
}