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000045389 0247_ $$2DOI$$a10.1007/s10541-005-0108-1
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000045389 084__ $$2WoS$$aBiochemistry & Molecular Biology
000045389 1001_ $$0P:(DE-HGF)0$$aMulkidjanian, A. Y.$$b0
000045389 245__ $$aProton transfer dynamics at membrane/water interface and mechanism of biological energy conversion
000045389 260__ $$aColumbus, Ohio$$bAmerican Chemical Society$$c2005
000045389 300__ $$a251 - 256
000045389 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
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000045389 440_0 $$0798$$aBiochemistry$$v70$$x0006-2960
000045389 500__ $$aRecord converted from VDB: 12.11.2012
000045389 520__ $$aPathogenesis of idiopathic pulmonary arterial hypertension (iPAH) includes endothelial dysfunction and in situ thrombosis. A hypercoagulable state has also been postulated but never demonstrated. Our objective was to determine whether patients with iPAH had a hypercoagulable state using calibrated automated thrombography (CAT), a new tool to phenotype coagulation in vitro.16 patients with iPAH and 29 controls were studied. In vitro platelet dependent coagulation phenotyping by CAT monitored the activity of thrombin generation over time. Plasma levels of soluble thrombomodulin, tissue factor pathway inhibitor (TFPI) and von Willebrand factor (VWF) were measured as endothelial biomarkers.Endogenous thrombin potential (ETP) in the absence of activated protein C (APC) tended to be increased in patients compared to controls (1769 versus 1656 nM.min; p=0.053). ETP was higher in the presence of APC 25 nM (ETP-APC) in patients (781 versus 494 nM.min; p=0.005). Five patients had ETP-APC higher than the 95th centile of controls. Other CAT parameters (lag time, peak thrombin and time to peak) were all consistent with some degree of hypercoagulability in patients. Regarding endothelial plasma biomarkers sTM was lower (28.4 versus 40.6 μg/l, p=0.0108) in patients; TFPI antigen and activity (respectively: 14.3 versus 10.5 μg/l, p=0.0167; 1.155 versus 1.070, p=0.0021) and VWF (1300 versus 976%, p=0.0108) were higher in patients.We have demonstrated that at least some patients with iPAH have a hypercoagulable phenotype.
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000045389 650_2 $$2MeSH$$aAdolescent
000045389 650_2 $$2MeSH$$aAdult
000045389 650_2 $$2MeSH$$aAged
000045389 650_2 $$2MeSH$$aAged, 80 and over
000045389 650_2 $$2MeSH$$aAutomation
000045389 650_2 $$2MeSH$$aBlood Coagulation Tests: methods
000045389 650_2 $$2MeSH$$aBlood Coagulation Tests: standards
000045389 650_2 $$2MeSH$$aCalibration
000045389 650_2 $$2MeSH$$aCase-Control Studies
000045389 650_2 $$2MeSH$$aEndothelium: metabolism
000045389 650_2 $$2MeSH$$aEndothelium: pathology
000045389 650_2 $$2MeSH$$aFemale
000045389 650_2 $$2MeSH$$aHumans
000045389 650_2 $$2MeSH$$aHypertension, Pulmonary: blood
000045389 650_2 $$2MeSH$$aHypertension, Pulmonary: pathology
000045389 650_2 $$2MeSH$$aHypertension, Pulmonary: physiopathology
000045389 650_2 $$2MeSH$$aMale
000045389 650_2 $$2MeSH$$aMiddle Aged
000045389 650_2 $$2MeSH$$aProspective Studies
000045389 650_2 $$2MeSH$$aPulmonary Artery: metabolism
000045389 650_2 $$2MeSH$$aPulmonary Artery: pathology
000045389 650_2 $$2MeSH$$aThrombophilia: blood
000045389 650_2 $$2MeSH$$aThrombophilia: diagnosis
000045389 650_2 $$2MeSH$$aThrombophilia: pathology
000045389 650_2 $$2MeSH$$aThrombophilia: physiopathology
000045389 650_2 $$2MeSH$$aYoung Adult
000045389 650_7 $$2WoSType$$aJ
000045389 65320 $$2Author$$aATP synthesis
000045389 65320 $$2Author$$amembrane potential
000045389 65320 $$2Author$$achemiosmotic coupling
000045389 65320 $$2Author$$aalkaliphilic bacteria
000045389 65320 $$2Author$$achloroplasts
000045389 65320 $$2Author$$amitochondria
000045389 65320 $$2Author$$abacterial membranes
000045389 7001_ $$0P:(DE-HGF)0$$aCherepanov, D. A.$$b1
000045389 7001_ $$0P:(DE-Juel1)VDB572$$aHeberle, J.$$b2$$uFZJ
000045389 7001_ $$0P:(DE-Juel1)VDB52678$$aJunge, W.$$b3$$uFZJ
000045389 773__ $$0PERI:(DE-600)1472258-6$$a10.1007/s10541-005-0108-1$$gVol. 70, p. 251 - 256$$p251 - 256$$q70<251 - 256$$tBiochemistry$$v70$$x0006-2960$$y2005
000045389 8567_ $$uhttp://hdl.handle.net/2128/704$$uhttp://dx.doi.org/10.1007/s10541-005-0108-1
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000045389 9201_ $$0I:(DE-Juel1)VDB58$$d31.12.2006$$gIBI$$kIBI-2$$lBiologische Strukturforschung$$x0
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