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@ARTICLE{Mulkidjanian:45389,
      author       = {Mulkidjanian, A. Y. and Cherepanov, D. A. and Heberle, J.
                      and Junge, W.},
      title        = {{P}roton transfer dynamics at membrane/water interface and
                      mechanism of biological energy conversion},
      journal      = {Biochemistry},
      volume       = {70},
      issn         = {0006-2960},
      address      = {Columbus, Ohio},
      publisher    = {American Chemical Society},
      reportid     = {PreJuSER-45389},
      pages        = {251 - 256},
      year         = {2005},
      note         = {Record converted from VDB: 12.11.2012},
      abstract     = {Pathogenesis of idiopathic pulmonary arterial hypertension
                      (iPAH) includes endothelial dysfunction and in situ
                      thrombosis. A hypercoagulable state has also been postulated
                      but never demonstrated. Our objective was to determine
                      whether patients with iPAH had a hypercoagulable state using
                      calibrated automated thrombography (CAT), a new tool to
                      phenotype coagulation in vitro.16 patients with iPAH and 29
                      controls were studied. In vitro platelet dependent
                      coagulation phenotyping by CAT monitored the activity of
                      thrombin generation over time. Plasma levels of soluble
                      thrombomodulin, tissue factor pathway inhibitor (TFPI) and
                      von Willebrand factor (VWF) were measured as endothelial
                      biomarkers.Endogenous thrombin potential (ETP) in the
                      absence of activated protein C (APC) tended to be increased
                      in patients compared to controls (1769 versus 1656 nM.min;
                      p=0.053). ETP was higher in the presence of APC 25 nM
                      (ETP-APC) in patients (781 versus 494 nM.min; p=0.005). Five
                      patients had ETP-APC higher than the 95th centile of
                      controls. Other CAT parameters (lag time, peak thrombin and
                      time to peak) were all consistent with some degree of
                      hypercoagulability in patients. Regarding endothelial plasma
                      biomarkers sTM was lower (28.4 versus 40.6 μg/l, p=0.0108)
                      in patients; TFPI antigen and activity (respectively: 14.3
                      versus 10.5 μg/l, p=0.0167; 1.155 versus 1.070, p=0.0021)
                      and VWF (1300 versus $976\%,$ p=0.0108) were higher in
                      patients.We have demonstrated that at least some patients
                      with iPAH have a hypercoagulable phenotype.},
      keywords     = {Adolescent / Adult / Aged / Aged, 80 and over / Automation
                      / Blood Coagulation Tests: methods / Blood Coagulation
                      Tests: standards / Calibration / Case-Control Studies /
                      Endothelium: metabolism / Endothelium: pathology / Female /
                      Humans / Hypertension, Pulmonary: blood / Hypertension,
                      Pulmonary: pathology / Hypertension, Pulmonary:
                      physiopathology / Male / Middle Aged / Prospective Studies /
                      Pulmonary Artery: metabolism / Pulmonary Artery: pathology /
                      Thrombophilia: blood / Thrombophilia: diagnosis /
                      Thrombophilia: pathology / Thrombophilia: physiopathology /
                      Young Adult / J (WoSType)},
      cin          = {IBI-2},
      ddc          = {570},
      cid          = {I:(DE-Juel1)VDB58},
      pnm          = {Neurowissenschaften},
      pid          = {G:(DE-Juel1)FUEK255},
      shelfmark    = {Biochemistry $\&$ Molecular Biology},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:20888030},
      UT           = {WOS:000227736500020},
      doi          = {10.1007/s10541-005-0108-1},
      url          = {https://juser.fz-juelich.de/record/45389},
}