Hauptseite > Publikationsdatenbank > Proton transfer dynamics at membrane/water interface and mechanism of biological energy conversion > print

001     45389
005     20200423204108.0
024 7 _ |a pmid:20888030
|2 pmid
024 7 _ |a 10.1007/s10541-005-0108-1
|2 DOI
024 7 _ |a WOS:000227736500020
|2 WOS
024 7 _ |a 2128/704
|2 Handle
037 _ _ |a PreJuSER-45389
041 _ _ |a eng
082 _ _ |a 570
084 _ _ |2 WoS
|a Biochemistry & Molecular Biology
100 1 _ |a Mulkidjanian, A. Y.
|b 0
|0 P:(DE-HGF)0
245 _ _ |a Proton transfer dynamics at membrane/water interface and mechanism of biological energy conversion
260 _ _ |a Columbus, Ohio
|b American Chemical Society
|c 2005
300 _ _ |a 251 - 256
336 7 _ |a Journal Article
|0 PUB:(DE-HGF)16
|2 PUB:(DE-HGF)
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|0 0
|2 EndNote
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a article
|2 DRIVER
440 _ 0 |a Biochemistry
|x 0006-2960
|0 798
|v 70
500 _ _ |a Record converted from VDB: 12.11.2012
520 _ _ |a Pathogenesis of idiopathic pulmonary arterial hypertension (iPAH) includes endothelial dysfunction and in situ thrombosis. A hypercoagulable state has also been postulated but never demonstrated. Our objective was to determine whether patients with iPAH had a hypercoagulable state using calibrated automated thrombography (CAT), a new tool to phenotype coagulation in vitro.16 patients with iPAH and 29 controls were studied. In vitro platelet dependent coagulation phenotyping by CAT monitored the activity of thrombin generation over time. Plasma levels of soluble thrombomodulin, tissue factor pathway inhibitor (TFPI) and von Willebrand factor (VWF) were measured as endothelial biomarkers.Endogenous thrombin potential (ETP) in the absence of activated protein C (APC) tended to be increased in patients compared to controls (1769 versus 1656 nM.min; p=0.053). ETP was higher in the presence of APC 25 nM (ETP-APC) in patients (781 versus 494 nM.min; p=0.005). Five patients had ETP-APC higher than the 95th centile of controls. Other CAT parameters (lag time, peak thrombin and time to peak) were all consistent with some degree of hypercoagulability in patients. Regarding endothelial plasma biomarkers sTM was lower (28.4 versus 40.6 μg/l, p=0.0108) in patients; TFPI antigen and activity (respectively: 14.3 versus 10.5 μg/l, p=0.0167; 1.155 versus 1.070, p=0.0021) and VWF (1300 versus 976%, p=0.0108) were higher in patients.We have demonstrated that at least some patients with iPAH have a hypercoagulable phenotype.
536 _ _ |a Neurowissenschaften
|c L01
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588 _ _ |a Dataset connected to Web of Science, Pubmed
650 _ 2 |2 MeSH
|a Adolescent
650 _ 2 |2 MeSH
|a Adult
650 _ 2 |2 MeSH
|a Aged
650 _ 2 |2 MeSH
|a Aged, 80 and over
650 _ 2 |2 MeSH
|a Automation
650 _ 2 |2 MeSH
|a Blood Coagulation Tests: methods
650 _ 2 |2 MeSH
|a Blood Coagulation Tests: standards
650 _ 2 |2 MeSH
|a Calibration
650 _ 2 |2 MeSH
|a Case-Control Studies
650 _ 2 |2 MeSH
|a Endothelium: metabolism
650 _ 2 |2 MeSH
|a Endothelium: pathology
650 _ 2 |2 MeSH
|a Female
650 _ 2 |2 MeSH
|a Humans
650 _ 2 |2 MeSH
|a Hypertension, Pulmonary: blood
650 _ 2 |2 MeSH
|a Hypertension, Pulmonary: pathology
650 _ 2 |2 MeSH
|a Hypertension, Pulmonary: physiopathology
650 _ 2 |2 MeSH
|a Male
650 _ 2 |2 MeSH
|a Middle Aged
650 _ 2 |2 MeSH
|a Prospective Studies
650 _ 2 |2 MeSH
|a Pulmonary Artery: metabolism
650 _ 2 |2 MeSH
|a Pulmonary Artery: pathology
650 _ 2 |2 MeSH
|a Thrombophilia: blood
650 _ 2 |2 MeSH
|a Thrombophilia: diagnosis
650 _ 2 |2 MeSH
|a Thrombophilia: pathology
650 _ 2 |2 MeSH
|a Thrombophilia: physiopathology
650 _ 2 |2 MeSH
|a Young Adult
650 _ 7 |a J
|2 WoSType
653 2 0 |2 Author
|a ATP synthesis
653 2 0 |2 Author
|a membrane potential
653 2 0 |2 Author
|a chemiosmotic coupling
653 2 0 |2 Author
|a alkaliphilic bacteria
653 2 0 |2 Author
|a chloroplasts
653 2 0 |2 Author
|a mitochondria
653 2 0 |2 Author
|a bacterial membranes
700 1 _ |a Cherepanov, D. A.
|b 1
|0 P:(DE-HGF)0
700 1 _ |a Heberle, J.
|b 2
|u FZJ
|0 P:(DE-Juel1)VDB572
700 1 _ |a Junge, W.
|b 3
|u FZJ
|0 P:(DE-Juel1)VDB52678
773 _ _ |a 10.1007/s10541-005-0108-1
|g Vol. 70, p. 251 - 256
|p 251 - 256
|q 70<251 - 256
|0 PERI:(DE-600)1472258-6
|t Biochemistry
|v 70
|y 2005
|x 0006-2960
856 7 _ |u http://dx.doi.org/10.1007/s10541-005-0108-1
|u http://hdl.handle.net/2128/704
856 4 _ |u https://juser.fz-juelich.de/record/45389/files/68946.pdf
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|y OpenAccess
909 C O |o oai:juser.fz-juelich.de:45389
|p openaire
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913 1 _ |k L01
|v Neurowissenschaften
|l Funktion und Dysfunktion des Nervensystems
|b Leben
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914 1 _ |y 2005
915 _ _ |0 StatID:(DE-HGF)0010
|a JCR/ISI refereed
915 _ _ |2 StatID
|0 StatID:(DE-HGF)0510
|a OpenAccess
920 1 _ |k IBI-2
|l Biologische Strukturforschung
|d 31.12.2006
|g IBI
|0 I:(DE-Juel1)VDB58
|x 0
970 _ _ |a VDB:(DE-Juel1)68946
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