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@ARTICLE{Schubert:46808,
      author       = {Schubert, D. and Staiger, J. F. and Cho, N. and Kötter, R.
                      and Zilles, K. and Luhmann, H. J.},
      title        = {{L}ayer-specific intracolumnar and transcolumnar functional
                      connectivity of layer {V} pyramidal cells in rat barrel
                      cortex},
      journal      = {The journal of neuroscience},
      volume       = {21},
      issn         = {0270-6474},
      address      = {Washington, DC},
      publisher    = {Soc.},
      reportid     = {PreJuSER-46808},
      pages        = {3580 - 3592},
      year         = {2001},
      note         = {Record converted from VDB: 12.11.2012},
      abstract     = {Layer V pyramidal cells in rat barrel cortex are considered
                      to play an important role in intracolumnar and transcolumnar
                      signal processing. However, the precise circuitry mediating
                      this processing is still incompletely understood. Here we
                      obtained detailed maps of excitatory and inhibitory synaptic
                      inputs onto the two major layer V pyramidal cell subtypes,
                      intrinsically burst spiking (IB) and regular spiking (RS)
                      cells, using a combination of caged glutamate photolysis,
                      whole- cell patch- clamp recording, and three- dimensional
                      reconstruction of biocytin- labeled cells. To excite
                      presynaptic neurons with laminar specificity, the release of
                      caged glutamate was calibrated and restricted to small areas
                      of 50 x 50 mum in all cortical layers and in at least two
                      neighboring barrel- related columns. IB cells received
                      intracolumnar excitatory input from all layers, with the
                      largest EPSP amplitudes originating from neurons in layers
                      IV and VI. Prominent transcolumnar excitatory inputs were
                      provided by presynaptic neurons also located in layers IV,
                      V, and VI of neighboring columns. Inhibitory inputs were
                      rare. In contrast, RS cells received distinct intracolumnar
                      inhibitory inputs, especially from layers II/ III and V.
                      Intracolumnar excitatory inputs to RS cells were prominent
                      from layers II- V, but relatively weak from layer VI.
                      Conspicuous transcolumnar excitatory inputs could be evoked
                      solely in layers IV and V. Our results show that layer V
                      pyramidal cells are synaptically driven by presynaptic
                      neurons located in every layer of the barrel cortex. RS
                      cells seem to be preferentially involved in intracolumnar
                      signal processing, whereas IB cells effectively integrate
                      excitatory inputs across several columns.},
      keywords     = {J (WoSType)},
      cin          = {IME},
      ddc          = {590},
      cid          = {I:(DE-Juel1)VDB54},
      pnm          = {Signaltransduktion},
      pid          = {G:(DE-Juel1)FUEK89},
      shelfmark    = {Neurosciences},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000168409400033},
      url          = {https://juser.fz-juelich.de/record/46808},
}