TY  - JOUR
AU  - Vogeley, K.
AU  - Bussfeld, P.
AU  - Newen, A.
AU  - Herrmann, S.
AU  - Happe, F.
AU  - Falkai, P.
AU  - Maier, W.
AU  - Shah, J. N.
AU  - Fink, G. R.
AU  - Zilles, K.
TI  - Mind reading : neural mechanisms of theory of mind and self-perspective
JO  - NeuroImage
VL  - 14
SN  - 1053-8119
CY  - Orlando, Fla.
PB  - Academic Press
M1  - PreJuSER-46850
SP  - 170 - 181
PY  - 2001
N1  - Record converted from VDB: 12.11.2012
AB  - Human self-consciousness as the metarepresentation of ones own mental states and the so-called theory of mind (TOM) capacity, which requires the ability to model the mental states of others, are closely related higher cognitive functions. We address here the issue of whether taking the self-perspective (SELF) or modeling the mind of someone else (TOM) employ the same or differential neural mechanisms. A TOM paradigm was used and extended to include stimulus material that involved TOM and SELF capacities in a two-way factorial design. A behavioral study in 42 healthy volunteers showed that TOM and SELF induced differential states of mind: subjects assigned correctly first or third person pronouns when providing responses to the stimuli. Following the behavioral study, we used functional magnetic resonance imaging (fMRI) in eight healthy, right-handed males to study the common and differential neural mechanisms underlying TOM and SELF. The main factor TOM led to increased neural activity in the anterior cingulate cortex and left temporopolar cortex. The main factor SELF led to increased neural activity in the right temporoparietal junction and in the anterior cingulate cortex. A significant interaction of both factors TOM and SELF was observed in the right prefrontal cortex. These divergent neural activations in response to TOM and SELF suggest that these important differential mental capacities of human self-consciousness are implemented at least in part in distinct brain regions. Press
KW  - Adult
KW  - Awareness: physiology
KW  - Brain Mapping
KW  - Dominance, Cerebral: physiology
KW  - Female
KW  - Gyrus Cinguli: physiology
KW  - Humans
KW  - Interpersonal Relations
KW  - Magnetic Resonance Imaging
KW  - Male
KW  - Mental Processes: physiology
KW  - Reference Values
KW  - Self Concept
KW  - Social Perception
KW  - Synaptic Transmission: physiology
KW  - Temporal Lobe: physiology
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
C6  - pmid:11525326
UR  - <Go to ISI:>//WOS:000169498000017
DO  - DOI:10.1006/nimg.2001.0789
UR  - https://juser.fz-juelich.de/record/46850
ER  -