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@ARTICLE{Acosta:47111,
      author       = {Acosta, R. H. and Blümler, P. and Agulles-Petrós, L. and
                      Morbach, A. E. and Schmiedeskamp, J. and Herweling, A. and
                      Wolf, U. and Scholz, A. and Schreiber, W. G. and Heil, W.
                      and Thelen, M. and Spies, H.-W.},
      title        = {{C}ontrolling diffusion of 3{H}e by buffer gases: a
                      structural contrast agent in lung {MRI}},
      journal      = {Journal of magnetic resonance imaging},
      volume       = {24},
      issn         = {1053-1807},
      address      = {New York, NY},
      publisher    = {Wiley-Liss},
      reportid     = {PreJuSER-47111},
      pages        = {1291 - 1297},
      year         = {2006},
      note         = {Record converted from VDB: 12.11.2012},
      abstract     = {To study the influence of admixing inert buffer gases to
                      laser-polarized (3)He in terms of resulting diffusion
                      coefficients and the consequences for image contrast and
                      resolution.The diffusion coefficient of (3)He was altered by
                      admixing buffer gases of various molecular weights ((4)He,
                      N(2), and SF(6)). The influence of the pulse sequence and
                      the diffusion coefficient on the appearance of MRI of
                      (laser-polarized) gases was analyzed by comparison of basic
                      theoretical concepts with demonstrative
                      experiments.Excellent agreement between theoretical
                      description and observed signal in simple gradient echoes
                      was observed. A maximum signal gain can be predicted and was
                      experimentally validated. Images acquired under such
                      conditions revealed improved resolution. The nature and
                      concentration of the admixed gas defines a structural
                      threshold for the observed apparent diffusion coefficient
                      (ADC) as demonstrated with diffusion-weighted MRI on a pig's
                      lung flooded with suitable gas mixtures.A novel procedure is
                      proposed to control the diffusion coefficient of gases in
                      MRI by admixture of inert buffer gases. Their molecular mass
                      and concentration enter as additional parameters into the
                      equations that describe structural contrast. This allows for
                      setting a structural threshold up to which structures
                      contribute to the image. For MRI of the lung this enables
                      images of very small structural elements (alveoli) only, or
                      in the other extreme, all airways can be displayed with
                      minimal signal loss due to diffusion.},
      keywords     = {Contrast Media: chemistry / Diffusion Magnetic Resonance
                      Imaging: instrumentation / Diffusion Magnetic Resonance
                      Imaging: methods / Gases: chemistry / Gases: diagnostic use
                      / Helium: chemistry / Helium: diagnostic use / Humans /
                      Image Enhancement: methods / Isotopes: chemistry / Isotopes:
                      diagnostic use / Lung: anatomy $\&$ histology / Lung:
                      chemistry / Phantoms, Imaging / Reproducibility of Results /
                      Sensitivity and Specificity / Contrast Media (NLM Chemicals)
                      / Gases (NLM Chemicals) / Isotopes (NLM Chemicals) / Helium
                      (NLM Chemicals) / J (WoSType)},
      cin          = {ICG-III},
      ddc          = {610},
      cid          = {I:(DE-Juel1)VDB49},
      pnm          = {Terrestrische Umwelt},
      pid          = {G:(DE-Juel1)FUEK407},
      shelfmark    = {Radiology, Nuclear Medicine $\&$ Medical Imaging},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:17078046},
      UT           = {WOS:000242562000012},
      doi          = {10.1002/jmri.20777},
      url          = {https://juser.fz-juelich.de/record/47111},
}