guest ::
| Home > Publications database > Glutamic acid-rich proteins of rod photoreceptors are natively unfolded > print |
| Home > Publications database > Glutamic acid-rich proteins of rod photoreceptors are natively unfolded > print |
| 001 | 49529 | ||
| 005 | 20200423204259.0 | ||
| 024 | 7 | _ | |a pmid:23115339 |2 pmid |
| 024 | 7 | _ | |a 10.1074/jbcM505012200 |2 DOI |
| 024 | 7 | _ | |a WOS:000234652000022 |2 WOS |
| 024 | 7 | _ | |a 2128/2646 |2 Handle |
| 037 | _ | _ | |a PreJuSER-49529 |
| 041 | _ | _ | |a ENG |
| 082 | _ | _ | |a 570 |
| 084 | _ | _ | |2 WoS |a Biochemistry & Molecular Biology |
| 100 | 1 | _ | |a Batra-Safferling, R. |b 0 |u FZJ |0 P:(DE-Juel1)VDB58515 |
| 245 | _ | _ | |a Glutamic acid-rich proteins of rod photoreceptors are natively unfolded |
| 260 | _ | _ | |a Bethesda, Md. |b Soc. |c 2006 |
| 300 | _ | _ | |a 1449 - 1460 |
| 336 | 7 | _ | |a Journal Article |0 PUB:(DE-HGF)16 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a article |2 DRIVER |
| 440 | _ | 0 | |a Journal of Biological Chemistry |x 0021-9258 |0 3091 |y 3 |v 281 |
| 500 | _ | _ | |a Record converted from VDB: 12.11.2012 |
| 520 | _ | _ | |a Broadly neutralizing HIV antibodies (bNAbs) can recognize carbohydrate-dependent epitopes on gp120. In contrast to previously characterized glycan-dependent bNAbs that recognize high-mannose N-glycans, PGT121 binds complex-type N-glycans in glycan microarrays. We isolated the B-cell clone encoding PGT121, which segregates into PGT121-like and 10-1074-like groups distinguished by sequence, binding affinity, carbohydrate recognition, and neutralizing activity. Group 10-1074 exhibits remarkable potency and breadth but no detectable binding to protein-free glycans. Crystal structures of unliganded PGT121, 10-1074, and their likely germ-line precursor reveal that differential carbohydrate recognition maps to a cleft between complementarity determining region (CDR)H2 and CDRH3. This cleft was occupied by a complex-type N-glycan in a "liganded" PGT121 structure. Swapping glycan contact residues between PGT121 and 10-1074 confirmed their importance for neutralization. Although PGT121 binds complex-type N-glycans, PGT121 recognized high-mannose-only HIV envelopes in isolation and on virions. As HIV envelopes exhibit varying proportions of high-mannose- and complex-type N-glycans, these results suggest promiscuous carbohydrate interactions, an advantageous adaptation ensuring neutralization of all viruses within a given strain. |
| 536 | _ | _ | |a Funktion und Dysfunktion des Nervensystems |c P33 |2 G:(DE-HGF) |0 G:(DE-Juel1)FUEK409 |x 0 |
| 588 | _ | _ | |a Dataset connected to Web of Science, Pubmed |
| 650 | _ | 7 | |a J |2 WoSType |
| 700 | 1 | _ | |a Abarca-Heidemann, K. |b 1 |u FZJ |0 P:(DE-Juel1)VDB58516 |
| 700 | 1 | _ | |a Körschen, H. G. |b 2 |u FZJ |0 P:(DE-Juel1)VDB31218 |
| 700 | 1 | _ | |a Tziatzios, C. |b 3 |0 P:(DE-HGF)0 |
| 700 | 1 | _ | |a Stoldt, M. |b 4 |u FZJ |0 P:(DE-Juel1)VDB21601 |
| 700 | 1 | _ | |a Budyak, I. |b 5 |u FZJ |0 P:(DE-Juel1)VDB44596 |
| 700 | 1 | _ | |a Willbold, D. |b 6 |u FZJ |0 P:(DE-Juel1)132029 |
| 700 | 1 | _ | |a Schwalbe, H. |b 7 |0 P:(DE-HGF)0 |
| 700 | 1 | _ | |a Klein-Seetharaman, J. |b 8 |u FZJ |0 P:(DE-Juel1)VDB44599 |
| 700 | 1 | _ | |a Kaupp, U. B. |b 9 |u FZJ |0 P:(DE-Juel1)VDB728 |
| 773 | _ | _ | |a 10.1074/jbcM505012200 |g Vol. 281, p. 1449 - 1460 |p 1449 - 1460 |q 281<1449 - 1460 |0 PERI:(DE-600)1474604-9 |t The @journal of biological chemistry |v 281 |y 2006 |x 0021-9258 |
| 856 | 7 | _ | |u http://dx.doi.org/10.1074/jbcM505012200 |u http://hdl.handle.net/2128/2646 |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/49529/files/77520.pdf |y OpenAccess |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/49529/files/77520.jpg?subformat=icon-1440 |x icon-1440 |y OpenAccess |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/49529/files/77520.jpg?subformat=icon-180 |x icon-180 |y OpenAccess |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/49529/files/77520.jpg?subformat=icon-640 |x icon-640 |y OpenAccess |
| 909 | C | O | |o oai:juser.fz-juelich.de:49529 |p openaire |p open_access |p driver |p VDB |p dnbdelivery |
| 913 | 1 | _ | |k P33 |v Funktion und Dysfunktion des Nervensystems |l Funktion und Dysfunktion des Nervensystems |b Gesundheit |0 G:(DE-Juel1)FUEK409 |x 0 |
| 914 | 1 | _ | |y 2006 |
| 915 | _ | _ | |0 StatID:(DE-HGF)0010 |a JCR/ISI refereed |
| 915 | _ | _ | |2 StatID |0 StatID:(DE-HGF)0510 |a OpenAccess |
| 920 | 1 | _ | |k IBI-1 |l Zelluläre Signalverarbeitung |d 31.12.2006 |g IBI |0 I:(DE-Juel1)VDB57 |x 0 |
| 920 | 1 | _ | |k IBI-2 |l Biologische Strukturforschung |d 31.12.2006 |g IBI |0 I:(DE-Juel1)VDB58 |x 1 |
| 970 | _ | _ | |a VDB:(DE-Juel1)77520 |
| 980 | 1 | _ | |a FullTexts |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a JUWEL |
| 980 | _ | _ | |a ConvertedRecord |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a I:(DE-Juel1)ICS-4-20110106 |
| 980 | _ | _ | |a I:(DE-Juel1)ISB-2-20090406 |
| 980 | _ | _ | |a UNRESTRICTED |
| 980 | _ | _ | |a I:(DE-Juel1)ICS-6-20110106 |
| 980 | _ | _ | |a FullTexts |
| 981 | _ | _ | |a I:(DE-Juel1)IBI-1-20200312 |
| 981 | _ | _ | |a I:(DE-Juel1)IBI-7-20200312 |
| 981 | _ | _ | |a I:(DE-Juel1)ICS-4-20110106 |
| 981 | _ | _ | |a I:(DE-Juel1)ISB-2-20090406 |
| 981 | _ | _ | |a I:(DE-Juel1)ICS-6-20110106 |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|