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@ARTICLE{Anastassiadis:49745,
      author       = {Anastassiadis, A. and Aivasidis, A. and Wandrey, C. and
                      Rehm, H.-J.},
      title        = {{P}rocess {O}ptimization of {C}ontinuous {G}luconic {A}cid
                      {F}ermentation by {I}solated {Y}east-{L}ike {S}trains of
                      {A}ureobasidium pullulans},
      journal      = {Biotechnology $\&$ bioengineering},
      volume       = {91},
      issn         = {0006-3592},
      address      = {New York, NY [u.a.]},
      publisher    = {Wiley},
      reportid     = {PreJuSER-49745},
      pages        = {494 - 501},
      year         = {2005},
      note         = {Record converted from VDB: 12.11.2012},
      abstract     = {This study was focused on the optimization of a new
                      fermentation process for continuous gluconic acid production
                      by the isolated yeast-like strain Aureobasidium pullulans
                      DSM 7085 (isolate 70). Operational fermentation parameters
                      were optimized in chemostat cultures, using a defined
                      glucose medium. Different optima were found for growth and
                      gluconic acid production for each set of operation
                      parameters. Highest productivity was recorded at pH values
                      between 6.5 and 7.0 and temperatures between 29 and 31
                      degrees C. A gluconic acid concentration higher than 230 g/L
                      was continuously produced at residence times of 12 h. A
                      steady state extracellular gluconic acid concentration of
                      234 g/L was measured at pH 6.5. $122\%$ air saturation
                      yielded the highest volumetric productivity and product
                      concentration. The biomass-specific productivity increased
                      steadily upon raising air saturation. An intracellular
                      gluconic acid concentration of about 159 g/L (0.83 mol) was
                      determined at 31 degrees C. This is to be compared with an
                      extracellular concentration of 223 g/L (1.16 mol), which
                      indicates the possible existence of an active transport
                      system for gluconic acid secretion, or the presence of
                      extracellular glucose oxidizing enzymes. The new process
                      provides significant advantages over the traditional
                      discontinuous fungi operations. The process control becomes
                      easier, thus offering stable product quality and quantity.},
      keywords     = {Ascomycota: enzymology / Ascomycota: physiology /
                      Bioreactors / Fermentation / Gluconates: metabolism / Hot
                      Temperature / Humidity / Hydrogen-Ion Concentration /
                      Microbiological Techniques: methods / Oxidation-Reduction /
                      Oxygen: metabolism / Gluconates (NLM Chemicals) / gluconic
                      acid (NLM Chemicals) / Oxygen (NLM Chemicals) / J (WoSType)},
      cin          = {IBT-2},
      ddc          = {570},
      cid          = {I:(DE-Juel1)VDB56},
      pnm          = {Biotechnologie},
      pid          = {G:(DE-Juel1)FUEK256},
      shelfmark    = {Biotechnology $\&$ Applied Microbiology},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:15937884},
      UT           = {WOS:000230915400012},
      doi          = {10.1002/bit.20533},
      url          = {https://juser.fz-juelich.de/record/49745},
}