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000049746 084__ $$2WoS$$aBiotechnology & Applied Microbiology
000049746 1001_ $$0P:(DE-HGF)0$$aAnastassiadis, A.$$b0
000049746 245__ $$aContinuous citric acid fermentation by Candida oleophila under nitrogen limitation at constant C/N ratio
000049746 260__ $$aDordrecht [u.a.]$$bSpringer Science + Business Media B.V$$c2005
000049746 300__ $$a695 - 705
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000049746 440_0 $$014825$$aWorld Journal of Microbiology & Biotechnology$$v21$$x0959-3993
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000049746 520__ $$aThe central aspect of this work was to investigate the influence of nitrogen feed rate at constant C/N ratio on continuous citric acid fermentation by Candida oleophila ATCC 20177. Medium ammonia nitrogen and glucose concentrations influenced growth and production. Space-time yield (STY) meaning volumetric productivity, biomass specific productivity (BSP), product concentration, product selectivity and citrate/isocitrate ratio increased with increasing residence time (RT). BSP increased in an exponential mode lowering nitrogen feed rates. Highest BSP for citric acid of 0.13 g/(g h) was achieved at lowest NH4Cl concentration of 1.5 g/l and highest STY (1.2 g/l h) with 3 g NH4Cl/l at a RT of 25 h. Citric acid 74.2 g/l were produced at 58 h RT and 6 g NH4Cl/l. Glucose uptake rate seems to be strictly controlled by the growth rate of the yeast cells. Optimum nitrogen concentration and adapted C/N ratio are essential for successful continuous citric acid fermentation. The biomass-specific nitrogen feed rate is the most important factor influencing continuous citric acid production by yeasts. Numerous chemostat experiments showed the feasibility of continuous citrate production by yeasts.
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000049746 65320 $$2Author$$aCandida oleophila
000049746 65320 $$2Author$$acitric acid production
000049746 65320 $$2Author$$acontinuous citric acid fermentation
000049746 65320 $$2Author$$anitrogen influence
000049746 65320 $$2Author$$aspecific nitrogen feed rate
000049746 65320 $$2Author$$aspecific active citrate transport system
000049746 7001_ $$0P:(DE-Juel1)129071$$aWandrey, C.$$b1$$uFZJ
000049746 7001_ $$0P:(DE-HGF)0$$aRehm, H.-J.$$b2
000049746 773__ $$0PERI:(DE-600)1499109-3$$a10.1007/s11274-004-3850-4$$gVol. 21, p. 695 - 705$$p695 - 705$$q21<695 - 705$$tWorld journal of microbiology and biotechnology$$v21$$x0959-3993$$y2005
000049746 8567_ $$uhttp://dx.doi.org/10.1007/s11274-004-3850-4
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000049746 9141_ $$y2005
000049746 915__ $$0StatID:(DE-HGF)0010$$aJCR/ISI refereed
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