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@ARTICLE{Anastassiadis:49746,
      author       = {Anastassiadis, A. and Wandrey, C. and Rehm, H.-J.},
      title        = {{C}ontinuous citric acid fermentation by {C}andida
                      oleophila under nitrogen limitation at constant {C}/{N}
                      ratio},
      journal      = {World journal of microbiology and biotechnology},
      volume       = {21},
      issn         = {0959-3993},
      address      = {Dordrecht [u.a.]},
      publisher    = {Springer Science + Business Media B.V},
      reportid     = {PreJuSER-49746},
      pages        = {695 - 705},
      year         = {2005},
      note         = {Record converted from VDB: 12.11.2012},
      abstract     = {The central aspect of this work was to investigate the
                      influence of nitrogen feed rate at constant C/N ratio on
                      continuous citric acid fermentation by Candida oleophila
                      ATCC 20177. Medium ammonia nitrogen and glucose
                      concentrations influenced growth and production. Space-time
                      yield (STY) meaning volumetric productivity, biomass
                      specific productivity (BSP), product concentration, product
                      selectivity and citrate/isocitrate ratio increased with
                      increasing residence time (RT). BSP increased in an
                      exponential mode lowering nitrogen feed rates. Highest BSP
                      for citric acid of 0.13 g/(g h) was achieved at lowest NH4Cl
                      concentration of 1.5 g/l and highest STY (1.2 g/l h) with 3
                      g NH4Cl/l at a RT of 25 h. Citric acid 74.2 g/l were
                      produced at 58 h RT and 6 g NH4Cl/l. Glucose uptake rate
                      seems to be strictly controlled by the growth rate of the
                      yeast cells. Optimum nitrogen concentration and adapted C/N
                      ratio are essential for successful continuous citric acid
                      fermentation. The biomass-specific nitrogen feed rate is the
                      most important factor influencing continuous citric acid
                      production by yeasts. Numerous chemostat experiments showed
                      the feasibility of continuous citrate production by yeasts.},
      keywords     = {J (WoSType)},
      cin          = {IBT-2},
      ddc          = {570},
      cid          = {I:(DE-Juel1)VDB56},
      pnm          = {Biotechnologie},
      pid          = {G:(DE-Juel1)FUEK256},
      shelfmark    = {Biotechnology $\&$ Applied Microbiology},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000232158900014},
      doi          = {10.1007/s11274-004-3850-4},
      url          = {https://juser.fz-juelich.de/record/49746},
}