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000049810 0247_ $$2DOI$$a10.1007/s00216-005-0181-8
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000049810 084__ $$2WoS$$aBiochemical Research Methods
000049810 084__ $$2WoS$$aChemistry, Analytical
000049810 1001_ $$0P:(DE-Juel1)129325$$aGünther, K.$$b0$$uFZJ
000049810 245__ $$aEstrogen-active nonylphenols from an isomer-specific viewpoint: a systematic numbering system and future trends
000049810 260__ $$aBerlin$$bSpringer$$c2006
000049810 300__ $$a542 - 546
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000049810 440_0 $$08664$$aAnalytical and Bioanalytical Chemistry$$v384$$x1618-2642$$y2
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000049810 520__ $$a4-Nonylphenols (NPs) are very important environmentally relevant substances. They are persistent, toxic, endocrine-disrupting chemicals that are priority hazardous substances of the EU Water Framework Directive. NPs are degradation products of 4-nonylphenol ethoxylates (NPEs), a widely used group of nonionic surfactants. The technical synthesis of NP leads to a complex mixture of NPs consisting of isomeric compounds that have different branched nonyl side chains. It has recently become clear that an isomer-specific view is absolutely necessary when it comes to correctly evaluating the biological effects of NPs and their behavior in the environment, including degradation processes. To rationalize the identification of individual NP isomers in scientific studies, we have developed a numbering system for all possible NP isomers that follows the IUPAC rules of substituent characterization in alkylphenols. The 211 possible constitutional isomers of NP are numbered according to a hierarchical and logical system. In the future, multidimensional coupling systems--for example GCxGC-TOF-MS--will be needed to study these highly complex class of substances.
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000049810 650_2 $$2MeSH$$aChemistry, Organic: methods
000049810 650_2 $$2MeSH$$aChemistry, Organic: trends
000049810 650_2 $$2MeSH$$aEstrogens: chemistry
000049810 650_2 $$2MeSH$$aIsomerism
000049810 650_2 $$2MeSH$$aMolecular Structure
000049810 650_2 $$2MeSH$$aPhenols: chemistry
000049810 650_2 $$2MeSH$$aTerminology as Topic
000049810 650_7 $$00$$2NLM Chemicals$$aEstrogens
000049810 650_7 $$00$$2NLM Chemicals$$aPhenols
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000049810 7001_ $$0P:(DE-Juel1)129345$$aKleist, E.$$b1$$uFZJ
000049810 7001_ $$0P:(DE-Juel1)129410$$aThiele, B.$$b2$$uFZJ
000049810 773__ $$0PERI:(DE-600)1459122-4$$a10.1007/s00216-005-0181-8$$gVol. 384, p. 542 - 546$$p542 - 546$$q384<542 - 546$$tAnalytical and bioanalytical chemistry$$v384$$x1618-2642$$y2006
000049810 8567_ $$uhttp://dx.doi.org/10.1007/s00216-005-0181-8
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