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000049899 0247_ $$2DOI$$a10.1007/s10874-006-9034-x
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000049899 084__ $$2WoS$$aEnvironmental Sciences
000049899 084__ $$2WoS$$aMeteorology & Atmospheric Sciences
000049899 1001_ $$0P:(DE-Juel1)VDB13401$$aKarl, M.$$b0$$uFZJ
000049899 245__ $$aProduct Study of the Reaction of OH Radicals with Isoprene in the Atmosphere Simulation Chamber SAPHIR
000049899 260__ $$aDordrecht [u.a.]$$bSpringer Science + Business Media B.V$$c2006
000049899 300__ $$a167 - 187
000049899 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
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000049899 440_0 $$03073$$aJournal of Atmospheric Chemistry$$v55$$x0167-7764
000049899 500__ $$aRecord converted from VDB: 12.11.2012
000049899 520__ $$aA previous study compared the effects of folate on methyl metabolism in colon and liver of rats fed a selenium-deficient diet (< 3 microg Se/kg) to those of rats fed a diet containing supranutritional Se (2 mg selenite/kg). The purpose of this study was to investigate the effects of folate and adequate Se (0.2 mg/kg) on methyl metabolism in colon and liver. Weanling, Fischer-344 rats (n = 8/diet) were fed diets containing 0 or 0.2 mg selenium (as selenite)/kg and 0 or 2 mg folic acid/kg in a 2 x 2 design. After 70 d, plasma homocysteine was increased (p < 0.0001) by folate deficiency; this increase was markedly attenuated (p < 0.0001) in rats fed the selenium-deficient diet compared to those fed 0.2 mg Se/kg. The activity of hepatic glycine N-methyltransferase (GNMT), an enzyme involved in the regulation of tissue S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH), was increased by folate deficiency (p < 0.006) and decreased by selenium deprivation (p < 0.0003). Colon and liver SAH were highest (p < 0.006) in rats fed deficient folate and adequate selenium. Although folate deficiency decreased liver SAM (p < 0.001), it had no effect on colon SAM. Global DNA methylation was decreased (p<0.04) by selenium deficiency in colon but not liver; folate had no effect. Selenium deficiency did not affect DNA methyltransferase (Dnmt) activity in liver but tended to decrease (p < 0.06) the activity of the enzyme in the colon. Dietary folate did not affect liver or colon Dnmt. These results in rats fed adequate selenium are similar to previous results found in rats fed supranutritional selenium. This suggests that selenium deficiency appears to be a more important modifier of methyl metabolism than either adequate or supplemental selenium.
000049899 536__ $$0G:(DE-Juel1)FUEK257$$2G:(DE-HGF)$$aChemie und Dynamik der Geo-Biosphäre$$cU01$$x0
000049899 588__ $$aDataset connected to Web of Science, Pubmed
000049899 650_2 $$2MeSH$$aAnimals
000049899 650_2 $$2MeSH$$aColon: cytology
000049899 650_2 $$2MeSH$$aColon: drug effects
000049899 650_2 $$2MeSH$$aColon: metabolism
000049899 650_2 $$2MeSH$$aDNA (Cytosine-5-)-Methyltransferase: metabolism
000049899 650_2 $$2MeSH$$aDNA Methylation: drug effects
000049899 650_2 $$2MeSH$$aDeficiency Diseases: metabolism
000049899 650_2 $$2MeSH$$aDeficiency Diseases: pathology
000049899 650_2 $$2MeSH$$aFolic Acid: administration & dosage
000049899 650_2 $$2MeSH$$aFolic Acid: metabolism
000049899 650_2 $$2MeSH$$aFolic Acid: pharmacology
000049899 650_2 $$2MeSH$$aGlutathione: blood
000049899 650_2 $$2MeSH$$aGlutathione: metabolism
000049899 650_2 $$2MeSH$$aGlutathione Peroxidase: metabolism
000049899 650_2 $$2MeSH$$aGlycine N-Methyltransferase: metabolism
000049899 650_2 $$2MeSH$$aHomocysteine: blood
000049899 650_2 $$2MeSH$$aHomocysteine: metabolism
000049899 650_2 $$2MeSH$$aLiver: cytology
000049899 650_2 $$2MeSH$$aLiver: drug effects
000049899 650_2 $$2MeSH$$aLiver: metabolism
000049899 650_2 $$2MeSH$$aMale
000049899 650_2 $$2MeSH$$aRats
000049899 650_2 $$2MeSH$$aRats, Inbred F344
000049899 650_2 $$2MeSH$$aS-Adenosylhomocysteine: metabolism
000049899 650_2 $$2MeSH$$aS-Adenosylmethionine: metabolism
000049899 650_2 $$2MeSH$$aSelenium: administration & dosage
000049899 650_2 $$2MeSH$$aSelenium: metabolism
000049899 650_2 $$2MeSH$$aSelenium: pharmacology
000049899 650_7 $$029908-03-0$$2NLM Chemicals$$aS-Adenosylmethionine
000049899 650_7 $$0454-28-4$$2NLM Chemicals$$aHomocysteine
000049899 650_7 $$059-30-3$$2NLM Chemicals$$aFolic Acid
000049899 650_7 $$070-18-8$$2NLM Chemicals$$aGlutathione
000049899 650_7 $$07782-49-2$$2NLM Chemicals$$aSelenium
000049899 650_7 $$0979-92-0$$2NLM Chemicals$$aS-Adenosylhomocysteine
000049899 650_7 $$0EC 1.11.1.9$$2NLM Chemicals$$aGlutathione Peroxidase
000049899 650_7 $$0EC 2.1.1.20$$2NLM Chemicals$$aGlycine N-Methyltransferase
000049899 650_7 $$0EC 2.1.1.20$$2NLM Chemicals$$aGnmt protein, rat
000049899 650_7 $$0EC 2.1.1.37$$2NLM Chemicals$$aDNA (Cytosine-5-)-Methyltransferase
000049899 650_7 $$2WoSType$$aJ
000049899 65320 $$2Author$$aatmosphere simulation chamber
000049899 65320 $$2Author$$aisoprene oxidation
000049899 65320 $$2Author$$amethacrolein
000049899 65320 $$2Author$$amethyl vinyl ketone
000049899 65320 $$2Author$$aOH radicals
000049899 65320 $$2Author$$atropospheric ozone
000049899 7001_ $$0P:(DE-Juel1)16317$$aDorn, H. P.$$b1$$uFZJ
000049899 7001_ $$0P:(DE-Juel1)16342$$aHolland, F.$$b2$$uFZJ
000049899 7001_ $$0P:(DE-Juel1)VDB810$$aKoppmann, R.$$b3$$uFZJ
000049899 7001_ $$0P:(DE-Juel1)16311$$aPoppe, D.$$b4$$uFZJ
000049899 7001_ $$0P:(DE-Juel1)VDB14753$$aRupp, L.$$b5$$uFZJ
000049899 7001_ $$0P:(DE-Juel1)VDB10108$$aSchaub, A.$$b6$$uFZJ
000049899 7001_ $$0P:(DE-Juel1)16324$$aWahner, A.$$b7$$uFZJ
000049899 773__ $$0PERI:(DE-600)1475524-5$$a10.1007/s10874-006-9034-x$$gVol. 55, p. 167 - 187$$p167 - 187$$q55<167 - 187$$tJournal of atmospheric chemistry$$v55$$x0167-7764$$y2006
000049899 8567_ $$uhttp://dx.doi.org/10.1007/s10874-006-9034-x
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000049899 9141_ $$y2006
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