% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Karl:49899,
      author       = {Karl, M. and Dorn, H. P. and Holland, F. and Koppmann, R.
                      and Poppe, D. and Rupp, L. and Schaub, A. and Wahner, A.},
      title        = {{P}roduct {S}tudy of the {R}eaction of {OH} {R}adicals with
                      {I}soprene in the {A}tmosphere {S}imulation {C}hamber
                      {SAPHIR}},
      journal      = {Journal of atmospheric chemistry},
      volume       = {55},
      issn         = {0167-7764},
      address      = {Dordrecht [u.a.]},
      publisher    = {Springer Science + Business Media B.V},
      reportid     = {PreJuSER-49899},
      pages        = {167 - 187},
      year         = {2006},
      note         = {Record converted from VDB: 12.11.2012},
      abstract     = {A previous study compared the effects of folate on methyl
                      metabolism in colon and liver of rats fed a
                      selenium-deficient diet (< 3 microg Se/kg) to those of rats
                      fed a diet containing supranutritional Se (2 mg
                      selenite/kg). The purpose of this study was to investigate
                      the effects of folate and adequate Se (0.2 mg/kg) on methyl
                      metabolism in colon and liver. Weanling, Fischer-344 rats (n
                      = 8/diet) were fed diets containing 0 or 0.2 mg selenium (as
                      selenite)/kg and 0 or 2 mg folic acid/kg in a 2 x 2 design.
                      After 70 d, plasma homocysteine was increased (p < 0.0001)
                      by folate deficiency; this increase was markedly attenuated
                      (p < 0.0001) in rats fed the selenium-deficient diet
                      compared to those fed 0.2 mg Se/kg. The activity of hepatic
                      glycine N-methyltransferase (GNMT), an enzyme involved in
                      the regulation of tissue S-adenosylmethionine (SAM) and
                      S-adenosylhomocysteine (SAH), was increased by folate
                      deficiency (p < 0.006) and decreased by selenium deprivation
                      (p < 0.0003). Colon and liver SAH were highest (p < 0.006)
                      in rats fed deficient folate and adequate selenium. Although
                      folate deficiency decreased liver SAM (p < 0.001), it had no
                      effect on colon SAM. Global DNA methylation was decreased
                      (p<0.04) by selenium deficiency in colon but not liver;
                      folate had no effect. Selenium deficiency did not affect DNA
                      methyltransferase (Dnmt) activity in liver but tended to
                      decrease (p < 0.06) the activity of the enzyme in the colon.
                      Dietary folate did not affect liver or colon Dnmt. These
                      results in rats fed adequate selenium are similar to
                      previous results found in rats fed supranutritional
                      selenium. This suggests that selenium deficiency appears to
                      be a more important modifier of methyl metabolism than
                      either adequate or supplemental selenium.},
      keywords     = {Animals / Colon: cytology / Colon: drug effects / Colon:
                      metabolism / DNA (Cytosine-5-)-Methyltransferase: metabolism
                      / DNA Methylation: drug effects / Deficiency Diseases:
                      metabolism / Deficiency Diseases: pathology / Folic Acid:
                      administration $\&$ dosage / Folic Acid: metabolism / Folic
                      Acid: pharmacology / Glutathione: blood / Glutathione:
                      metabolism / Glutathione Peroxidase: metabolism / Glycine
                      N-Methyltransferase: metabolism / Homocysteine: blood /
                      Homocysteine: metabolism / Liver: cytology / Liver: drug
                      effects / Liver: metabolism / Male / Rats / Rats, Inbred
                      F344 / S-Adenosylhomocysteine: metabolism /
                      S-Adenosylmethionine: metabolism / Selenium: administration
                      $\&$ dosage / Selenium: metabolism / Selenium: pharmacology
                      / S-Adenosylmethionine (NLM Chemicals) / Homocysteine (NLM
                      Chemicals) / Folic Acid (NLM Chemicals) / Glutathione (NLM
                      Chemicals) / Selenium (NLM Chemicals) /
                      S-Adenosylhomocysteine (NLM Chemicals) / Glutathione
                      Peroxidase (NLM Chemicals) / Glycine N-Methyltransferase
                      (NLM Chemicals) / Gnmt protein, rat (NLM Chemicals) / DNA
                      (Cytosine-5-)-Methyltransferase (NLM Chemicals) / J
                      (WoSType)},
      cin          = {ICG-2 / JARA-SIM / JARA-ENERGY},
      ddc          = {540},
      cid          = {I:(DE-Juel1)VDB791 / I:(DE-Juel1)VDB1045 /
                      $I:(DE-82)080011_20140620$},
      pnm          = {Chemie und Dynamik der Geo-Biosphäre},
      pid          = {G:(DE-Juel1)FUEK257},
      shelfmark    = {Environmental Sciences / Meteorology $\&$ Atmospheric
                      Sciences},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:16632891},
      UT           = {WOS:000240803000004},
      doi          = {10.1007/s10874-006-9034-x},
      url          = {https://juser.fz-juelich.de/record/49899},
}