001     49899
005     20240709081620.0
024 7 _ |2 pmid
|a pmid:16632891
024 7 _ |2 DOI
|a 10.1007/s10874-006-9034-x
024 7 _ |2 WOS
|a WOS:000240803000004
037 _ _ |a PreJuSER-49899
041 _ _ |a eng
082 _ _ |a 540
084 _ _ |2 WoS
|a Environmental Sciences
084 _ _ |2 WoS
|a Meteorology & Atmospheric Sciences
100 1 _ |a Karl, M.
|b 0
|u FZJ
|0 P:(DE-Juel1)VDB13401
245 _ _ |a Product Study of the Reaction of OH Radicals with Isoprene in the Atmosphere Simulation Chamber SAPHIR
260 _ _ |a Dordrecht [u.a.]
|b Springer Science + Business Media B.V
|c 2006
300 _ _ |a 167 - 187
336 7 _ |a Journal Article
|0 PUB:(DE-HGF)16
|2 PUB:(DE-HGF)
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|0 0
|2 EndNote
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a article
|2 DRIVER
440 _ 0 |a Journal of Atmospheric Chemistry
|x 0167-7764
|0 3073
|v 55
500 _ _ |a Record converted from VDB: 12.11.2012
520 _ _ |a A previous study compared the effects of folate on methyl metabolism in colon and liver of rats fed a selenium-deficient diet (< 3 microg Se/kg) to those of rats fed a diet containing supranutritional Se (2 mg selenite/kg). The purpose of this study was to investigate the effects of folate and adequate Se (0.2 mg/kg) on methyl metabolism in colon and liver. Weanling, Fischer-344 rats (n = 8/diet) were fed diets containing 0 or 0.2 mg selenium (as selenite)/kg and 0 or 2 mg folic acid/kg in a 2 x 2 design. After 70 d, plasma homocysteine was increased (p < 0.0001) by folate deficiency; this increase was markedly attenuated (p < 0.0001) in rats fed the selenium-deficient diet compared to those fed 0.2 mg Se/kg. The activity of hepatic glycine N-methyltransferase (GNMT), an enzyme involved in the regulation of tissue S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH), was increased by folate deficiency (p < 0.006) and decreased by selenium deprivation (p < 0.0003). Colon and liver SAH were highest (p < 0.006) in rats fed deficient folate and adequate selenium. Although folate deficiency decreased liver SAM (p < 0.001), it had no effect on colon SAM. Global DNA methylation was decreased (p<0.04) by selenium deficiency in colon but not liver; folate had no effect. Selenium deficiency did not affect DNA methyltransferase (Dnmt) activity in liver but tended to decrease (p < 0.06) the activity of the enzyme in the colon. Dietary folate did not affect liver or colon Dnmt. These results in rats fed adequate selenium are similar to previous results found in rats fed supranutritional selenium. This suggests that selenium deficiency appears to be a more important modifier of methyl metabolism than either adequate or supplemental selenium.
536 _ _ |a Chemie und Dynamik der Geo-Biosphäre
|c U01
|2 G:(DE-HGF)
|0 G:(DE-Juel1)FUEK257
|x 0
588 _ _ |a Dataset connected to Web of Science, Pubmed
650 _ 2 |2 MeSH
|a Animals
650 _ 2 |2 MeSH
|a Colon: cytology
650 _ 2 |2 MeSH
|a Colon: drug effects
650 _ 2 |2 MeSH
|a Colon: metabolism
650 _ 2 |2 MeSH
|a DNA (Cytosine-5-)-Methyltransferase: metabolism
650 _ 2 |2 MeSH
|a DNA Methylation: drug effects
650 _ 2 |2 MeSH
|a Deficiency Diseases: metabolism
650 _ 2 |2 MeSH
|a Deficiency Diseases: pathology
650 _ 2 |2 MeSH
|a Folic Acid: administration & dosage
650 _ 2 |2 MeSH
|a Folic Acid: metabolism
650 _ 2 |2 MeSH
|a Folic Acid: pharmacology
650 _ 2 |2 MeSH
|a Glutathione: blood
650 _ 2 |2 MeSH
|a Glutathione: metabolism
650 _ 2 |2 MeSH
|a Glutathione Peroxidase: metabolism
650 _ 2 |2 MeSH
|a Glycine N-Methyltransferase: metabolism
650 _ 2 |2 MeSH
|a Homocysteine: blood
650 _ 2 |2 MeSH
|a Homocysteine: metabolism
650 _ 2 |2 MeSH
|a Liver: cytology
650 _ 2 |2 MeSH
|a Liver: drug effects
650 _ 2 |2 MeSH
|a Liver: metabolism
650 _ 2 |2 MeSH
|a Male
650 _ 2 |2 MeSH
|a Rats
650 _ 2 |2 MeSH
|a Rats, Inbred F344
650 _ 2 |2 MeSH
|a S-Adenosylhomocysteine: metabolism
650 _ 2 |2 MeSH
|a S-Adenosylmethionine: metabolism
650 _ 2 |2 MeSH
|a Selenium: administration & dosage
650 _ 2 |2 MeSH
|a Selenium: metabolism
650 _ 2 |2 MeSH
|a Selenium: pharmacology
650 _ 7 |0 29908-03-0
|2 NLM Chemicals
|a S-Adenosylmethionine
650 _ 7 |0 454-28-4
|2 NLM Chemicals
|a Homocysteine
650 _ 7 |0 59-30-3
|2 NLM Chemicals
|a Folic Acid
650 _ 7 |0 70-18-8
|2 NLM Chemicals
|a Glutathione
650 _ 7 |0 7782-49-2
|2 NLM Chemicals
|a Selenium
650 _ 7 |0 979-92-0
|2 NLM Chemicals
|a S-Adenosylhomocysteine
650 _ 7 |0 EC 1.11.1.9
|2 NLM Chemicals
|a Glutathione Peroxidase
650 _ 7 |0 EC 2.1.1.20
|2 NLM Chemicals
|a Glycine N-Methyltransferase
650 _ 7 |0 EC 2.1.1.20
|2 NLM Chemicals
|a Gnmt protein, rat
650 _ 7 |0 EC 2.1.1.37
|2 NLM Chemicals
|a DNA (Cytosine-5-)-Methyltransferase
650 _ 7 |a J
|2 WoSType
653 2 0 |2 Author
|a atmosphere simulation chamber
653 2 0 |2 Author
|a isoprene oxidation
653 2 0 |2 Author
|a methacrolein
653 2 0 |2 Author
|a methyl vinyl ketone
653 2 0 |2 Author
|a OH radicals
653 2 0 |2 Author
|a tropospheric ozone
700 1 _ |a Dorn, H. P.
|b 1
|u FZJ
|0 P:(DE-Juel1)16317
700 1 _ |a Holland, F.
|b 2
|u FZJ
|0 P:(DE-Juel1)16342
700 1 _ |a Koppmann, R.
|b 3
|u FZJ
|0 P:(DE-Juel1)VDB810
700 1 _ |a Poppe, D.
|b 4
|u FZJ
|0 P:(DE-Juel1)16311
700 1 _ |a Rupp, L.
|b 5
|u FZJ
|0 P:(DE-Juel1)VDB14753
700 1 _ |a Schaub, A.
|b 6
|u FZJ
|0 P:(DE-Juel1)VDB10108
700 1 _ |a Wahner, A.
|b 7
|u FZJ
|0 P:(DE-Juel1)16324
773 _ _ |a 10.1007/s10874-006-9034-x
|g Vol. 55, p. 167 - 187
|p 167 - 187
|q 55<167 - 187
|0 PERI:(DE-600)1475524-5
|t Journal of atmospheric chemistry
|v 55
|y 2006
|x 0167-7764
856 7 _ |u http://dx.doi.org/10.1007/s10874-006-9034-x
909 C O |o oai:juser.fz-juelich.de:49899
|p VDB
913 1 _ |k U01
|v Chemie und Dynamik der Geo-Biosphäre
|l Chemie und Dynamik der Geo-Biosphäre
|b Environment (Umwelt)
|0 G:(DE-Juel1)FUEK257
|x 0
914 1 _ |y 2006
915 _ _ |0 StatID:(DE-HGF)0010
|a JCR/ISI refereed
920 1 _ |d 30.09.2010
|g ICG
|k ICG-2
|l Troposphäre
|0 I:(DE-Juel1)VDB791
|x 1
920 1 _ |0 I:(DE-Juel1)VDB1045
|k JARA-SIM
|l Jülich-Aachen Research Alliance - Simulation Sciences
|g JARA
|x 2
920 1 _ |0 I:(DE-82)080011_20140620
|k JARA-ENERGY
|l Jülich-Aachen Research Alliance - Energy
|g JARA
|x 3
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980 _ _ |a VDB
980 _ _ |a ConvertedRecord
980 _ _ |a journal
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980 _ _ |a I:(DE-Juel1)VDB1045
980 _ _ |a I:(DE-82)080011_20140620
980 _ _ |a UNRESTRICTED
981 _ _ |a I:(DE-Juel1)ICE-3-20101013
981 _ _ |a I:(DE-Juel1)IEK-8-20101013
981 _ _ |a I:(DE-Juel1)VDB1045
981 _ _ |a I:(DE-Juel1)VDB1047


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