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000050124 084__ $$2WoS$$aRespiratory System
000050124 1001_ $$0P:(DE-HGF)0$$aBarker, M.$$b0
000050124 245__ $$aVolatile organic compounds in the exhaled breath of young patients with cystic fibrosis
000050124 260__ $$aLausanne$$bERS$$c2006
000050124 300__ $$a929 - 936
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000050124 440_0 $$015201$$aEuropean Respiratory Journal$$v27$$x0903-1936
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000050124 520__ $$aInflammatory mediators in the exhaled breath are receiving growing medical interest as noninvasive disease markers. Volatile organic compounds have been investigated in this context, but clinical information and methodological standards are limited. The levels of ethane, propane, n-pentane, methanol, ethanol, 2-propanol, acetone, isoprene, benzene, toluene, dimethyl sulphide (DMS) and limonene were measured in repeated breath samples from 20 cystic fibrosis patients and 20 healthy controls (aged 8-29 yrs). Three end-exhaled and one ambient air sample were collected per person and analysed on a customised gas chromatography system. Intra-subject coefficients of variation ranged between 9 and 34%, and hydrocarbon breath levels were influenced by their inspired concentrations. The alveolar gradient for pentane was higher in cystic fibrosis patients than in healthy controls (0.36 versus 0.21 ppb) and inversely proportional to forced expiratory volume in one second; highest values were observed in patients with pulmonary exacerbations (0.73 versus 0.24 ppb). Cystic fibrosis patients also exhibited a lower output of DMS (3.9 versus 7.6 ppb). Group differences were not significant for ethane and the remaining substances. It was concluded that chemical breath analysis for volatile organic compounds is feasible and may hold potential for the noninvasive diagnosis and follow-up of inflammatory processes in cystic fibrosis lung disease.
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000050124 65320 $$2Author$$abiological markers
000050124 65320 $$2Author$$abreath tests
000050124 65320 $$2Author$$acystic fibrosis
000050124 65320 $$2Author$$agas chromatography
000050124 650_2 $$2MeSH$$a2-Propanol: metabolism
000050124 650_2 $$2MeSH$$aAcetone: metabolism
000050124 650_2 $$2MeSH$$aAdolescent
000050124 650_2 $$2MeSH$$aAdult
000050124 650_2 $$2MeSH$$aBenzene: metabolism
000050124 650_2 $$2MeSH$$aBreath Tests
000050124 650_2 $$2MeSH$$aButadienes: metabolism
000050124 650_2 $$2MeSH$$aChild
000050124 650_2 $$2MeSH$$aCyclohexenes: metabolism
000050124 650_2 $$2MeSH$$aCystic Fibrosis: metabolism
000050124 650_2 $$2MeSH$$aEthane: metabolism
000050124 650_2 $$2MeSH$$aEthanol: metabolism
000050124 650_2 $$2MeSH$$aExhalation
000050124 650_2 $$2MeSH$$aFemale
000050124 650_2 $$2MeSH$$aHemiterpenes: metabolism
000050124 650_2 $$2MeSH$$aHumans
000050124 650_2 $$2MeSH$$aMale
000050124 650_2 $$2MeSH$$aMethanol: metabolism
000050124 650_2 $$2MeSH$$aPentanes: metabolism
000050124 650_2 $$2MeSH$$aPropane: metabolism
000050124 650_2 $$2MeSH$$aSulfides: metabolism
000050124 650_2 $$2MeSH$$aTerpenes: metabolism
000050124 650_2 $$2MeSH$$aToluene: metabolism
000050124 650_7 $$00$$2NLM Chemicals$$aButadienes
000050124 650_7 $$00$$2NLM Chemicals$$aCyclohexenes
000050124 650_7 $$00$$2NLM Chemicals$$aHemiterpenes
000050124 650_7 $$00$$2NLM Chemicals$$aPentanes
000050124 650_7 $$00$$2NLM Chemicals$$aSulfides
000050124 650_7 $$00$$2NLM Chemicals$$aTerpenes
000050124 650_7 $$0108-88-3$$2NLM Chemicals$$aToluene
000050124 650_7 $$0109-66-0$$2NLM Chemicals$$apentane
000050124 650_7 $$0138-86-3$$2NLM Chemicals$$alimonene
000050124 650_7 $$064-17-5$$2NLM Chemicals$$aEthanol
000050124 650_7 $$067-56-1$$2NLM Chemicals$$aMethanol
000050124 650_7 $$067-63-0$$2NLM Chemicals$$a2-Propanol
000050124 650_7 $$067-64-1$$2NLM Chemicals$$aAcetone
000050124 650_7 $$071-43-2$$2NLM Chemicals$$aBenzene
000050124 650_7 $$074-84-0$$2NLM Chemicals$$aEthane
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000050124 650_7 $$075-18-3$$2NLM Chemicals$$adimethyl sulfide
000050124 650_7 $$078-79-5$$2NLM Chemicals$$aisoprene
000050124 650_7 $$2WoSType$$aJ
000050124 7001_ $$0P:(DE-HGF)0$$aHengst, M.$$b1
000050124 7001_ $$0P:(DE-HGF)0$$aSchmid, J.$$b2
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000050124 7001_ $$0P:(DE-Juel1)133810$$aMittermaier, B.$$b4$$uFZJ
000050124 7001_ $$0P:(DE-Juel1)16218$$aKlemp, D.$$b5$$ufzj
000050124 7001_ $$0P:(DE-Juel1)VDB810$$aKoppmann, R.$$b6$$uFZJ
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000050124 8567_ $$uhttp://hdl.handle.net/2128/397$$uhttp://dx.doi.org/10.1183/09031936.06.00085105
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