TY  - JOUR
AU  - Barker, M.
AU  - Hengst, M.
AU  - Schmid, J.
AU  - Buers, H.-J.
AU  - Mittermaier, B.
AU  - Klemp, D.
AU  - Koppmann, R.
TI  - Volatile organic compounds in the exhaled breath of young patients with cystic fibrosis
JO  - European respiratory journal
VL  - 27
SN  - 0903-1936
CY  - Lausanne
PB  - ERS
M1  - PreJuSER-50124
SP  - 929 - 936
PY  - 2006
N1  - Record converted from VDB: 12.11.2012
AB  - Inflammatory mediators in the exhaled breath are receiving growing medical interest as noninvasive disease markers. Volatile organic compounds have been investigated in this context, but clinical information and methodological standards are limited. The levels of ethane, propane, n-pentane, methanol, ethanol, 2-propanol, acetone, isoprene, benzene, toluene, dimethyl sulphide (DMS) and limonene were measured in repeated breath samples from 20 cystic fibrosis patients and 20 healthy controls (aged 8-29 yrs). Three end-exhaled and one ambient air sample were collected per person and analysed on a customised gas chromatography system. Intra-subject coefficients of variation ranged between 9 and 34%, and hydrocarbon breath levels were influenced by their inspired concentrations. The alveolar gradient for pentane was higher in cystic fibrosis patients than in healthy controls (0.36 versus 0.21 ppb) and inversely proportional to forced expiratory volume in one second; highest values were observed in patients with pulmonary exacerbations (0.73 versus 0.24 ppb). Cystic fibrosis patients also exhibited a lower output of DMS (3.9 versus 7.6 ppb). Group differences were not significant for ethane and the remaining substances. It was concluded that chemical breath analysis for volatile organic compounds is feasible and may hold potential for the noninvasive diagnosis and follow-up of inflammatory processes in cystic fibrosis lung disease.
KW  - 2-Propanol: metabolism
KW  - Acetone: metabolism
KW  - Adolescent
KW  - Adult
KW  - Benzene: metabolism
KW  - Breath Tests
KW  - Butadienes: metabolism
KW  - Child
KW  - Cyclohexenes: metabolism
KW  - Cystic Fibrosis: metabolism
KW  - Ethane: metabolism
KW  - Ethanol: metabolism
KW  - Exhalation
KW  - Female
KW  - Hemiterpenes: metabolism
KW  - Humans
KW  - Male
KW  - Methanol: metabolism
KW  - Pentanes: metabolism
KW  - Propane: metabolism
KW  - Sulfides: metabolism
KW  - Terpenes: metabolism
KW  - Toluene: metabolism
KW  - Butadienes (NLM Chemicals)
KW  - Cyclohexenes (NLM Chemicals)
KW  - Hemiterpenes (NLM Chemicals)
KW  - Pentanes (NLM Chemicals)
KW  - Sulfides (NLM Chemicals)
KW  - Terpenes (NLM Chemicals)
KW  - Toluene (NLM Chemicals)
KW  - pentane (NLM Chemicals)
KW  - limonene (NLM Chemicals)
KW  - Ethanol (NLM Chemicals)
KW  - Methanol (NLM Chemicals)
KW  - 2-Propanol (NLM Chemicals)
KW  - Acetone (NLM Chemicals)
KW  - Benzene (NLM Chemicals)
KW  - Ethane (NLM Chemicals)
KW  - Propane (NLM Chemicals)
KW  - dimethyl sulfide (NLM Chemicals)
KW  - isoprene (NLM Chemicals)
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
C6  - pmid:16455833
UR  - <Go to ISI:>//WOS:000237237100013
DO  - DOI:10.1183/09031936.06.00085105
UR  - https://juser.fz-juelich.de/record/50124
ER  -