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@ARTICLE{Barker:50124,
      author       = {Barker, M. and Hengst, M. and Schmid, J. and Buers, H.-J.
                      and Mittermaier, B. and Klemp, D. and Koppmann, R.},
      title        = {{V}olatile organic compounds in the exhaled breath of young
                      patients with cystic fibrosis},
      journal      = {European respiratory journal},
      volume       = {27},
      issn         = {0903-1936},
      address      = {Lausanne},
      publisher    = {ERS},
      reportid     = {PreJuSER-50124},
      pages        = {929 - 936},
      year         = {2006},
      note         = {Record converted from VDB: 12.11.2012},
      abstract     = {Inflammatory mediators in the exhaled breath are receiving
                      growing medical interest as noninvasive disease markers.
                      Volatile organic compounds have been investigated in this
                      context, but clinical information and methodological
                      standards are limited. The levels of ethane, propane,
                      n-pentane, methanol, ethanol, 2-propanol, acetone, isoprene,
                      benzene, toluene, dimethyl sulphide (DMS) and limonene were
                      measured in repeated breath samples from 20 cystic fibrosis
                      patients and 20 healthy controls (aged 8-29 yrs). Three
                      end-exhaled and one ambient air sample were collected per
                      person and analysed on a customised gas chromatography
                      system. Intra-subject coefficients of variation ranged
                      between 9 and $34\%,$ and hydrocarbon breath levels were
                      influenced by their inspired concentrations. The alveolar
                      gradient for pentane was higher in cystic fibrosis patients
                      than in healthy controls (0.36 versus 0.21 ppb) and
                      inversely proportional to forced expiratory volume in one
                      second; highest values were observed in patients with
                      pulmonary exacerbations (0.73 versus 0.24 ppb). Cystic
                      fibrosis patients also exhibited a lower output of DMS (3.9
                      versus 7.6 ppb). Group differences were not significant for
                      ethane and the remaining substances. It was concluded that
                      chemical breath analysis for volatile organic compounds is
                      feasible and may hold potential for the noninvasive
                      diagnosis and follow-up of inflammatory processes in cystic
                      fibrosis lung disease.},
      keywords     = {2-Propanol: metabolism / Acetone: metabolism / Adolescent /
                      Adult / Benzene: metabolism / Breath Tests / Butadienes:
                      metabolism / Child / Cyclohexenes: metabolism / Cystic
                      Fibrosis: metabolism / Ethane: metabolism / Ethanol:
                      metabolism / Exhalation / Female / Hemiterpenes: metabolism
                      / Humans / Male / Methanol: metabolism / Pentanes:
                      metabolism / Propane: metabolism / Sulfides: metabolism /
                      Terpenes: metabolism / Toluene: metabolism / Butadienes (NLM
                      Chemicals) / Cyclohexenes (NLM Chemicals) / Hemiterpenes
                      (NLM Chemicals) / Pentanes (NLM Chemicals) / Sulfides (NLM
                      Chemicals) / Terpenes (NLM Chemicals) / Toluene (NLM
                      Chemicals) / pentane (NLM Chemicals) / limonene (NLM
                      Chemicals) / Ethanol (NLM Chemicals) / Methanol (NLM
                      Chemicals) / 2-Propanol (NLM Chemicals) / Acetone (NLM
                      Chemicals) / Benzene (NLM Chemicals) / Ethane (NLM
                      Chemicals) / Propane (NLM Chemicals) / dimethyl sulfide (NLM
                      Chemicals) / isoprene (NLM Chemicals) / J (WoSType)},
      cin          = {ICG-II / ZB},
      ddc          = {610},
      cid          = {I:(DE-Juel1)VDB48 / I:(DE-Juel1)ZB-20090406},
      pnm          = {Atmosphäre und Klima},
      pid          = {G:(DE-Juel1)FUEK406},
      shelfmark    = {Respiratory System},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:16455833},
      UT           = {WOS:000237237100013},
      doi          = {10.1183/09031936.06.00085105},
      url          = {https://juser.fz-juelich.de/record/50124},
}