Home > Publications database > Volatile organic compounds in the exhaled breath of young patients with cystic fibrosis > print

001     50124
005     20240712101016.0
024 7 _ |a pmid:16455833
|2 pmid
024 7 _ |a 10.1183/09031936.06.00085105
|2 DOI
024 7 _ |a WOS:000237237100013
|2 WOS
024 7 _ |a 2128/397
|2 Handle
024 7 _ |a altmetric:21814770
|2 altmetric
037 _ _ |a PreJuSER-50124
041 _ _ |a eng
082 _ _ |a 610
084 _ _ |2 WoS
|a Respiratory System
100 1 _ |a Barker, M.
|b 0
|0 P:(DE-HGF)0
245 _ _ |a Volatile organic compounds in the exhaled breath of young patients with cystic fibrosis
260 _ _ |a Lausanne
|b ERS
|c 2006
300 _ _ |a 929 - 936
336 7 _ |a Journal Article
|0 PUB:(DE-HGF)16
|2 PUB:(DE-HGF)
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|0 0
|2 EndNote
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a article
|2 DRIVER
440 _ 0 |a European Respiratory Journal
|x 0903-1936
|0 15201
|v 27
500 _ _ |a Record converted from VDB: 12.11.2012
520 _ _ |a Inflammatory mediators in the exhaled breath are receiving growing medical interest as noninvasive disease markers. Volatile organic compounds have been investigated in this context, but clinical information and methodological standards are limited. The levels of ethane, propane, n-pentane, methanol, ethanol, 2-propanol, acetone, isoprene, benzene, toluene, dimethyl sulphide (DMS) and limonene were measured in repeated breath samples from 20 cystic fibrosis patients and 20 healthy controls (aged 8-29 yrs). Three end-exhaled and one ambient air sample were collected per person and analysed on a customised gas chromatography system. Intra-subject coefficients of variation ranged between 9 and 34%, and hydrocarbon breath levels were influenced by their inspired concentrations. The alveolar gradient for pentane was higher in cystic fibrosis patients than in healthy controls (0.36 versus 0.21 ppb) and inversely proportional to forced expiratory volume in one second; highest values were observed in patients with pulmonary exacerbations (0.73 versus 0.24 ppb). Cystic fibrosis patients also exhibited a lower output of DMS (3.9 versus 7.6 ppb). Group differences were not significant for ethane and the remaining substances. It was concluded that chemical breath analysis for volatile organic compounds is feasible and may hold potential for the noninvasive diagnosis and follow-up of inflammatory processes in cystic fibrosis lung disease.
536 _ _ |a Atmosphäre und Klima
|c P22
|2 G:(DE-HGF)
|0 G:(DE-Juel1)FUEK406
|x 0
588 _ _ |a Dataset connected to Web of Science, Pubmed
650 _ 2 |2 MeSH
|a 2-Propanol: metabolism
650 _ 2 |2 MeSH
|a Acetone: metabolism
650 _ 2 |2 MeSH
|a Adolescent
650 _ 2 |2 MeSH
|a Adult
650 _ 2 |2 MeSH
|a Benzene: metabolism
650 _ 2 |2 MeSH
|a Breath Tests
650 _ 2 |2 MeSH
|a Butadienes: metabolism
650 _ 2 |2 MeSH
|a Child
650 _ 2 |2 MeSH
|a Cyclohexenes: metabolism
650 _ 2 |2 MeSH
|a Cystic Fibrosis: metabolism
650 _ 2 |2 MeSH
|a Ethane: metabolism
650 _ 2 |2 MeSH
|a Ethanol: metabolism
650 _ 2 |2 MeSH
|a Exhalation
650 _ 2 |2 MeSH
|a Female
650 _ 2 |2 MeSH
|a Hemiterpenes: metabolism
650 _ 2 |2 MeSH
|a Humans
650 _ 2 |2 MeSH
|a Male
650 _ 2 |2 MeSH
|a Methanol: metabolism
650 _ 2 |2 MeSH
|a Pentanes: metabolism
650 _ 2 |2 MeSH
|a Propane: metabolism
650 _ 2 |2 MeSH
|a Sulfides: metabolism
650 _ 2 |2 MeSH
|a Terpenes: metabolism
650 _ 2 |2 MeSH
|a Toluene: metabolism
650 _ 7 |0 0
|2 NLM Chemicals
|a Butadienes
650 _ 7 |0 0
|2 NLM Chemicals
|a Cyclohexenes
650 _ 7 |0 0
|2 NLM Chemicals
|a Hemiterpenes
650 _ 7 |0 0
|2 NLM Chemicals
|a Pentanes
650 _ 7 |0 0
|2 NLM Chemicals
|a Sulfides
650 _ 7 |0 0
|2 NLM Chemicals
|a Terpenes
650 _ 7 |0 108-88-3
|2 NLM Chemicals
|a Toluene
650 _ 7 |0 109-66-0
|2 NLM Chemicals
|a pentane
650 _ 7 |0 138-86-3
|2 NLM Chemicals
|a limonene
650 _ 7 |0 64-17-5
|2 NLM Chemicals
|a Ethanol
650 _ 7 |0 67-56-1
|2 NLM Chemicals
|a Methanol
650 _ 7 |0 67-63-0
|2 NLM Chemicals
|a 2-Propanol
650 _ 7 |0 67-64-1
|2 NLM Chemicals
|a Acetone
650 _ 7 |0 71-43-2
|2 NLM Chemicals
|a Benzene
650 _ 7 |0 74-84-0
|2 NLM Chemicals
|a Ethane
650 _ 7 |0 74-98-6
|2 NLM Chemicals
|a Propane
650 _ 7 |0 75-18-3
|2 NLM Chemicals
|a dimethyl sulfide
650 _ 7 |0 78-79-5
|2 NLM Chemicals
|a isoprene
650 _ 7 |a J
|2 WoSType
653 2 0 |2 Author
|a biological markers
653 2 0 |2 Author
|a breath tests
653 2 0 |2 Author
|a cystic fibrosis
653 2 0 |2 Author
|a gas chromatography
700 1 _ |a Hengst, M.
|b 1
|0 P:(DE-HGF)0
700 1 _ |a Schmid, J.
|b 2
|0 P:(DE-HGF)0
700 1 _ |a Buers, H.-J.
|b 3
|u FZJ
|0 P:(DE-Juel1)129185
700 1 _ |a Mittermaier, B.
|b 4
|u FZJ
|0 P:(DE-Juel1)133810
700 1 _ |a Klemp, D.
|b 5
|0 P:(DE-Juel1)16218
|u fzj
700 1 _ |a Koppmann, R.
|b 6
|u FZJ
|0 P:(DE-Juel1)VDB810
773 _ _ |a 10.1183/09031936.06.00085105
|g p. 929 - 936
|p 929 - 936
|q 929 - 936
|0 PERI:(DE-600)1499101-9
|t European respiratory journal
|y 2006
|x 0903-1936
856 7 _ |u http://dx.doi.org/10.1183/09031936.06.00085105
|u http://hdl.handle.net/2128/397
856 4 _ |u https://juser.fz-juelich.de/record/50124/files/VOC%20in%20exhaled%20breath.doc
|y OpenAccess
856 4 _ |u https://juser.fz-juelich.de/record/50124/files/929.full.pdf
|y OpenAccess
909 C O |o oai:juser.fz-juelich.de:50124
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913 1 _ |k P22
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914 1 _ |y 2006
915 _ _ |0 StatID:(DE-HGF)0010
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915 _ _ |2 StatID
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920 1 _ |k ICG-II
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