TY  - JOUR
AU  - Schilbach, L.
AU  - Wohlschläger, A.
AU  - Kraemer, N. C.
AU  - Newen, A.
AU  - Shah, J. N.
AU  - Fink, G. R.
AU  - Vogeley, K.
TI  - Being with virtual others: Neural correlates of social interaction
JO  - Neuropsychologia
VL  - 44
SN  - 0028-3932
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - PreJuSER-50694
SP  - 718 - 730
PY  - 2006
N1  - Record converted from VDB: 12.11.2012
AB  - To characterize the neural correlates of being personally involved in social interaction as opposed to being a passive observer of social interaction between others we performed an fMRI study in which participants were gazed at by virtual characters (ME) or observed them looking at someone else (OTHER). In dynamic animations virtual characters then showed socially relevant facial expressions as they would appear in greeting and approach situations (SOC) or arbitrary facial movements (ARB). Differential neural activity associated with ME>OTHER was located in anterior medial prefrontal cortex in contrast to the precuneus for OTHER>ME. Perception of socially relevant facial expressions (SOC>ARB) led to differentially increased neural activity in ventral medial prefrontal cortex. Perception of arbitrary facial movements (ARB>SOC) differentially activated the middle temporal gyrus. The results, thus, show that activation of medial prefrontal cortex underlies both the perception of social communication indicated by facial expressions and the feeling of personal involvement indicated by eye gaze. Our data also demonstrate that distinct regions of medial prefrontal cortex contribute differentially to social cognition: whereas the ventral medial prefrontal cortex is recruited during the analysis of social content as accessible in interactionally relevant mimic gestures, differential activation of a more dorsal part of medial prefrontal cortex subserves the detection of self-relevance and may thus establish an intersubjective context in which communicative signals are evaluated.
KW  - Adult
KW  - Brain Mapping
KW  - Emotions: physiology
KW  - Face
KW  - Facial Expression
KW  - Female
KW  - Functional Laterality: physiology
KW  - Humans
KW  - Image Processing, Computer-Assisted: methods
KW  - Interpersonal Relations
KW  - Magnetic Resonance Imaging: methods
KW  - Male
KW  - Movement: physiology
KW  - Oxygen: blood
KW  - Prefrontal Cortex: blood supply
KW  - Prefrontal Cortex: physiology
KW  - Social Perception
KW  - Oxygen (NLM Chemicals)
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
C6  - pmid:16171833
UR  - <Go to ISI:>//WOS:000236813200005
DO  - DOI:10.1016/j.neuropsychologia.2005.07.017
UR  - https://juser.fz-juelich.de/record/50694
ER  -