TY  - JOUR
AU  - Kastenholz, B.
TI  - Important contributions of a new quantitative preparative native continuous polyacrylamide gel electrophoresis (QPNC-PAGE) procedure for elucidating metal cofactor metabolisms in protein-misfolding diseases - a theory
JO  - Protein and peptide letters
VL  - 13
SN  - 0929-8665
CY  - Schiphol
PB  - Bentham Science Publ.
M1  - PreJuSER-50735
SP  - 503 - 508
PY  - 2006
N1  - Record converted from VDB: 12.11.2012
AB  - The quantitative analysis of metallochaperone proteins in biofluids (e.g. blood, liquor) may be a major prerequisite for clinical investigations concerning the structure-function relationships of biologically-active metal cofactor-containing chaperones in protein-misfolding diseases (e.g. Alzheimer's or related diseases). For these purposes, a new state-of-the-art gel electrophoresis [quantitative preparative native continuous polyacrylamide gel electrophoresis procedure (QPNC-PAGE)] combined with biological mass and NMR spectrometrics might essentially contribute to provide fundamental insights into the metabolisms of important metal cofactors in biological systems and the proper folding of metallochaperones in conformational diseases.
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000237935900015
DO  - DOI:10.2174/092986606776819637
UR  - https://juser.fz-juelich.de/record/50735
ER  -