TY  - JOUR
AU  - Palomero-Gallagher, N.
AU  - Vogt, B.A.
AU  - Schleicher, A.
AU  - Mayberg, H.S.
AU  - Zilles, K.
TI  - Receptor Architecture of Human Cingulate Cortex: Evaluation of the Four-Region Neurobiological Model
JO  - Human brain mapping
VL  - 30
SN  - 1065-9471
CY  - New York, NY
PB  - Wiley-Liss
M1  - PreJuSER-5149
SP  - 2336 - 2355
PY  - 2009
N1  - Contract grant sponsor: National Institute of Mental Health, of Neurological Disorders and Stroke, of Drug Abuse, and the National Cancer Centre (KZ); The National Institutes of Health and the National Institute of Neurological Disorders and Stroke; Contract grant number: RO1 NS44222.
AB  - The structural and functional organization of the human cingulate cortex is an ongoing focus; however, human imaging studies continue to use the century-old Brodmann concept of a two region cingulate cortex. Recently, a four-region neurobiological model was proposed based on structural, circuitry, and functional imaging observations. It encompasses the anterior cingulate, midcingulate, posterior cingulate, and retrosplenial cortices (ACC, MCC, PCC, and RSC, respectively). For the first time, this study performs multireceptor autoradiography of 15 neurotransmitter receptor ligands and multivariate statistics on human whole brain postmortem samples covering the entire cingulate cortex. We evaluated the validity of Brodmann's duality concept and of the four-region model using a hierarchical clustering analysis of receptor binding according to the degree of similarity of each area's receptor architecture. We could not find support for Brodmann's dual cingulate concept, because the anterior part of his area 24 has significantly higher AMPA, kainate, GABA(B), benzodiazepine, and M(3) but lower NMDA and GABA(A) binding site densities than the posterior part. The hierarchical clustering analysis distinguished ACC, MCC, PCC, and RSC as independent regions. The ACC has highest AMPA, kainate, alpha(2), 5-HT(1A), and D(1) but lowest GABA(A) densities. The MCC has lowest AMPA, kainate, alpha(2), and D(1) densities. Area 25 in ACC is similar in receptor-architecture to MCC, particularly the NMDA, GABA(A), GABA(B), and M(2) receptors. The PCC and RSC differ in the higher M(1) and alpha(1) but lower M(3) densities of PCC. Thus, multireceptor autoradiography supports the four-region neurobiological model of the cingulate cortex.
KW  - Aged
KW  - Algorithms
KW  - Autoradiography
KW  - Cluster Analysis
KW  - Densitometry
KW  - Female
KW  - Gyrus Cinguli: anatomy & histology
KW  - Gyrus Cinguli: metabolism
KW  - Humans
KW  - Image Processing, Computer-Assisted
KW  - Male
KW  - Models, Neurological
KW  - Multivariate Analysis
KW  - Receptors, Adrenergic: metabolism
KW  - Receptors, Cholinergic: metabolism
KW  - Receptors, Dopamine D1: metabolism
KW  - Receptors, GABA: metabolism
KW  - Receptors, Glutamate: metabolism
KW  - Receptors, Serotonin: metabolism
KW  - Receptors, Adrenergic (NLM Chemicals)
KW  - Receptors, Cholinergic (NLM Chemicals)
KW  - Receptors, Dopamine D1 (NLM Chemicals)
KW  - Receptors, GABA (NLM Chemicals)
KW  - Receptors, Glutamate (NLM Chemicals)
KW  - Receptors, Serotonin (NLM Chemicals)
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
C6  - pmid:19034899
UR  - <Go to ISI:>//WOS:000268698700002
DO  - DOI:10.1002/hbm.20667
UR  - https://juser.fz-juelich.de/record/5149
ER  -