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@ARTICLE{PalomeroGallagher:5149,
      author       = {Palomero-Gallagher, N. and Vogt, B.A. and Schleicher, A.
                      and Mayberg, H.S. and Zilles, K.},
      title        = {{R}eceptor {A}rchitecture of {H}uman {C}ingulate {C}ortex:
                      {E}valuation of the {F}our-{R}egion {N}eurobiological
                      {M}odel},
      journal      = {Human brain mapping},
      volume       = {30},
      issn         = {1065-9471},
      address      = {New York, NY},
      publisher    = {Wiley-Liss},
      reportid     = {PreJuSER-5149},
      pages        = {2336 - 2355},
      year         = {2009},
      note         = {Contract grant sponsor: National Institute of Mental
                      Health, of Neurological Disorders and Stroke, of Drug Abuse,
                      and the National Cancer Centre (KZ); The National Institutes
                      of Health and the National Institute of Neurological
                      Disorders and Stroke; Contract grant number: RO1 NS44222.},
      abstract     = {The structural and functional organization of the human
                      cingulate cortex is an ongoing focus; however, human imaging
                      studies continue to use the century-old Brodmann concept of
                      a two region cingulate cortex. Recently, a four-region
                      neurobiological model was proposed based on structural,
                      circuitry, and functional imaging observations. It
                      encompasses the anterior cingulate, midcingulate, posterior
                      cingulate, and retrosplenial cortices (ACC, MCC, PCC, and
                      RSC, respectively). For the first time, this study performs
                      multireceptor autoradiography of 15 neurotransmitter
                      receptor ligands and multivariate statistics on human whole
                      brain postmortem samples covering the entire cingulate
                      cortex. We evaluated the validity of Brodmann's duality
                      concept and of the four-region model using a hierarchical
                      clustering analysis of receptor binding according to the
                      degree of similarity of each area's receptor architecture.
                      We could not find support for Brodmann's dual cingulate
                      concept, because the anterior part of his area 24 has
                      significantly higher AMPA, kainate, GABA(B), benzodiazepine,
                      and M(3) but lower NMDA and GABA(A) binding site densities
                      than the posterior part. The hierarchical clustering
                      analysis distinguished ACC, MCC, PCC, and RSC as independent
                      regions. The ACC has highest AMPA, kainate, alpha(2),
                      5-HT(1A), and D(1) but lowest GABA(A) densities. The MCC has
                      lowest AMPA, kainate, alpha(2), and D(1) densities. Area 25
                      in ACC is similar in receptor-architecture to MCC,
                      particularly the NMDA, GABA(A), GABA(B), and M(2) receptors.
                      The PCC and RSC differ in the higher M(1) and alpha(1) but
                      lower M(3) densities of PCC. Thus, multireceptor
                      autoradiography supports the four-region neurobiological
                      model of the cingulate cortex.},
      keywords     = {Aged / Algorithms / Autoradiography / Cluster Analysis /
                      Densitometry / Female / Gyrus Cinguli: anatomy $\&$
                      histology / Gyrus Cinguli: metabolism / Humans / Image
                      Processing, Computer-Assisted / Male / Models, Neurological
                      / Multivariate Analysis / Receptors, Adrenergic: metabolism
                      / Receptors, Cholinergic: metabolism / Receptors, Dopamine
                      D1: metabolism / Receptors, GABA: metabolism / Receptors,
                      Glutamate: metabolism / Receptors, Serotonin: metabolism /
                      Receptors, Adrenergic (NLM Chemicals) / Receptors,
                      Cholinergic (NLM Chemicals) / Receptors, Dopamine D1 (NLM
                      Chemicals) / Receptors, GABA (NLM Chemicals) / Receptors,
                      Glutamate (NLM Chemicals) / Receptors, Serotonin (NLM
                      Chemicals) / J (WoSType)},
      cin          = {INM-2 / JARA-BRAIN},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-2-20090406 / $I:(DE-82)080010_20140620$},
      pnm          = {Funktion und Dysfunktion des Nervensystems},
      pid          = {G:(DE-Juel1)FUEK409},
      shelfmark    = {Neurosciences / Neuroimaging / Radiology, Nuclear Medicine
                      $\&$ Medical Imaging},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:19034899},
      UT           = {WOS:000268698700002},
      doi          = {10.1002/hbm.20667},
      url          = {https://juser.fz-juelich.de/record/5149},
}