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| Hauptseite > Publikationsdatenbank > Cholinergic filtering in the recurrent excitatory microcircuit of cortical layer 4 > print |
| Hauptseite > Publikationsdatenbank > Cholinergic filtering in the recurrent excitatory microcircuit of cortical layer 4 > print |
| 001 | 5150 | ||
| 005 | 20180208195903.0 | ||
| 024 | 7 | _ | |2 pmid |a pmid:19564614 |
| 024 | 7 | _ | |2 pmc |a pmc:PMC2710689 |
| 024 | 7 | _ | |2 DOI |a 10.1073/pnas.0810062106 |
| 024 | 7 | _ | |2 WOS |a WOS:000267972700060 |
| 037 | _ | _ | |a PreJuSER-5150 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 000 |
| 084 | _ | _ | |2 WoS |a Multidisciplinary Sciences |
| 100 | 1 | _ | |0 P:(DE-HGF)0 |a Eggermann, E. |b 0 |
| 245 | _ | _ | |a Cholinergic filtering in the recurrent excitatory microcircuit of cortical layer 4 |
| 260 | _ | _ | |a Washington, DC |b Academy |c 2009 |
| 300 | _ | _ | |a 11753 - 11758 |
| 336 | 7 | _ | |a Journal Article |0 PUB:(DE-HGF)16 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a article |2 DRIVER |
| 440 | _ | 0 | |0 5100 |a Proceedings of the National Academy of Sciences of the United States of America |v 106 |x 0027-8424 |y 28 |
| 500 | _ | _ | |a We thank M. Muhlethaler, M. Serafin, A. Kerr, S. Williams, and R. Bruno for their comments and W. Hucko for excellent technical assistance. This work was supported by Swiss National Foundation Grant (E. E.), German-Israeli-Foundation Grant I-748-158.1/2002, and the Helmholtz Society. |
| 520 | _ | _ | |a Neocortical acetylcholine (ACH) release is known to enhance signal processing by increasing the amplitude and signal-to-noise ratio (SNR) of sensory responses. It is widely accepted that the larger sensory responses are caused by a persistent increase in the excitability of all cortical excitatory neurons. Here, contrary to this concept, we show that ACH persistently inhibits layer 4 (L4) spiny neurons, the main targets of thalamocortical inputs. Using whole-cell recordings in slices of rat primary somatosensory cortex, we demonstrate that this inhibition is specific to L4 and contrasts with the ACH-induced persistent excitation of pyramidal cells in L2/3 and L5. We find that this inhibition is induced by postsynaptic M(4)-muscarinic ACH receptors and is mediated by the opening of inwardly rectifying potassium (K(ir)) channels. Pair recordings of L4 spiny neurons show that ACH reduces synaptic release in the L4 recurrent microcircuit. We conclude that ACH has a differential layer-specific effect that results in a filtering of weak sensory inputs in the L4 recurrent excitatory microcircuit and a subsequent amplification of relevant inputs in L2/3 and L5 excitatory microcircuits. This layer-specific effect may contribute to improve cortical SNR. |
| 536 | _ | _ | |0 G:(DE-Juel1)FUEK409 |2 G:(DE-HGF) |a Funktion und Dysfunktion des Nervensystems |c P33 |x 0 |
| 588 | _ | _ | |a Dataset connected to Web of Science, Pubmed |
| 650 | _ | 2 | |2 MeSH |a Acetylcholine: metabolism |
| 650 | _ | 2 | |2 MeSH |a Acetylcholine: pharmacology |
| 650 | _ | 2 | |2 MeSH |a Afferent Pathways: physiology |
| 650 | _ | 2 | |2 MeSH |a Animals |
| 650 | _ | 2 | |2 MeSH |a Neurons: drug effects |
| 650 | _ | 2 | |2 MeSH |a Neurons: metabolism |
| 650 | _ | 2 | |2 MeSH |a Potassium Channels, Inwardly Rectifying: metabolism |
| 650 | _ | 2 | |2 MeSH |a Rats |
| 650 | _ | 2 | |2 MeSH |a Rats, Wistar |
| 650 | _ | 2 | |2 MeSH |a Receptors, Muscarinic: metabolism |
| 650 | _ | 2 | |2 MeSH |a Somatosensory Cortex: metabolism |
| 650 | _ | 2 | |2 MeSH |a Synaptic Transmission: drug effects |
| 650 | _ | 2 | |2 MeSH |a Synaptic Transmission: physiology |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Potassium Channels, Inwardly Rectifying |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Receptors, Muscarinic |
| 650 | _ | 7 | |0 51-84-3 |2 NLM Chemicals |a Acetylcholine |
| 650 | _ | 7 | |2 WoSType |a J |
| 653 | 2 | 0 | |2 Author |a acetylcholine |
| 653 | 2 | 0 | |2 Author |a muscarinic receptors |
| 653 | 2 | 0 | |2 Author |a sensory cortex |
| 653 | 2 | 0 | |2 Author |a synaptic transmission |
| 700 | 1 | _ | |0 P:(DE-Juel1)131680 |a Feldmeyer, D. |b 1 |u FZJ |
| 773 | _ | _ | |0 PERI:(DE-600)1461794-8 |a 10.1073/pnas.0810062106 |g Vol. 106, p. 11753 - 11758 |p 11753 - 11758 |q 106<11753 - 11758 |t Proceedings of the National Academy of Sciences of the United States of America |v 106 |x 0027-8424 |y 2009 |
| 856 | 7 | _ | |2 Pubmed Central |u http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2710689 |
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| 914 | 1 | _ | |y 2009 |
| 915 | _ | _ | |0 StatID:(DE-HGF)0010 |a JCR/ISI refereed |
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