TY  - JOUR
AU  - Bode, S.
AU  - Wolberg, M.
AU  - Müller, M.
TI  - Stereoselective Synthesis of 1,3-diols
JO  - Synthesis
SN  - 0039-7881
CY  - Stuttgart [u.a.]
PB  - Thieme
M1  - PreJuSER-52117
SP  - 557 - 588
PY  - 2006
N1  - Record converted from VDB: 12.11.2012
AB  - Many polyketide-derived natural products contain a synor anti-1,3-diol unit. No general and simple approach exists for the flexible synthesis of polyols and other polyketide-derived structural units, therefore a multitude of methods for the stereoselective synthesis of 1,3-diols has been developed. Asymmetric homogeneous and heterogeneous hydrogenation and diastereoselective reduction, chain elongation, enzymatic and nonenzymatic desymmetrization, or dynamic kinetic resolution are some of these methods. The development of different methods to synthesize these 1,3-diols stereoselectively is important, as often small structural changes in a molecule result in low yields or low stereoselectivity with a known method. This review article highlights some of the recent developments in this field.
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000235670600001
DO  - DOI:10.1055/s-2006-926315
UR  - https://juser.fz-juelich.de/record/52117
ER  -