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017 _ _ |a This version is available at the following Publisher URL: http://www.biophysj.org/
024 7 _ |a pmid:16679375
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024 7 _ |a pmc:PMC1563762
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024 7 _ |a 10.1529/biophysj.106.081422
|2 DOI
024 7 _ |a WOS:000239086800008
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024 7 _ |a 2128/1537
|2 Handle
037 _ _ |a PreJuSER-52397
041 _ _ |a eng
082 _ _ |a 570
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|a Biophysics
100 1 _ |a Vliegenthart, G. A.
|b 0
|u FZJ
|0 P:(DE-Juel1)VDB10822
245 _ _ |a Mechanical Deformation of Spherical Viruses with Icosahedral Symmetry
260 _ _ |a New York, NY
|b Rockefeller Univ. Press
|c 2006
300 _ _ |a 834 - 841
336 7 _ |a Journal Article
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336 7 _ |a article
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440 _ 0 |a Biophysical Journal
|x 0006-3495
|0 882
|v 91
500 _ _ |a Record converted from VDB: 12.11.2012
520 _ _ |a Virus capsids and crystalline surfactant vesicles are two examples of self-assembled shells in the nano- to micrometer size range. Virus capsids are particularly interesting since they have to sustain large internal pressures while encapsulating and protecting the viral DNA. We therefore study the mechanical properties of crystalline shells of icosahedral symmetry on a substrate under a uniaxial applied force by computer simulations. We predict the elastic response for small deformations, and the buckling transitions at large deformations. Both are found to depend strongly on the number of elementary building blocks N (the capsomers in the case of viral shells), the Föppl-von Kármán number gamma (which characterizes the relative importance of shear and bending elasticity), and the confining geometry. In particular, we show that whereas large shells are well described by continuum elasticity-theory, small shells of the size of typical viral capsids behave differently already for small deformations. Our results are essential to extract quantitative information about the elastic properties of viruses and vesicles from deformation experiments.
536 _ _ |a Kondensierte Materie
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650 _ 2 |2 MeSH
|a Biophysics: methods
650 _ 2 |2 MeSH
|a Capsid: chemistry
650 _ 2 |2 MeSH
|a Capsid Proteins
650 _ 2 |2 MeSH
|a Computer Simulation
650 _ 2 |2 MeSH
|a Elasticity
650 _ 2 |2 MeSH
|a Kinetics
650 _ 2 |2 MeSH
|a Models, Statistical
650 _ 2 |2 MeSH
|a Virus Assembly
650 _ 2 |2 MeSH
|a Virus Physiological Phenomena
650 _ 2 |2 MeSH
|a Viruses: chemistry
650 _ 7 |0 0
|2 NLM Chemicals
|a Capsid Proteins
650 _ 7 |a J
|2 WoSType
700 1 _ |a Gompper, G.
|b 1
|u FZJ
|0 P:(DE-Juel1)130665
773 _ _ |a 10.1529/biophysj.106.081422
|g Vol. 91, p. 834 - 841
|p 834 - 841
|q 91<834 - 841
|0 PERI:(DE-600)1477214-0
|t Biophysical journal
|v 91
|y 2006
|x 0006-3495
856 7 _ |2 Pubmed Central
|u http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1563762
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