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000005301 0247_ $$2DOI$$a10.1159/000233254
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000005301 041__ $$aeng
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000005301 084__ $$2WoS$$aCell Biology
000005301 084__ $$2WoS$$aPhysiology
000005301 1001_ $$0P:(DE-Juel1)VDB1208$$aPalomero-Gallagher, N.$$b0$$uFZJ
000005301 245__ $$aNeurotransmitter Receptor Imbalances in Motor Cortex and Basal Ganglia in Hepatic Encephalopathy
000005301 260__ $$aBasel$$bKarger$$c2009
000005301 300__ $$a
000005301 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
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000005301 3367_ $$2BibTeX$$aARTICLE
000005301 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000005301 3367_ $$2DRIVER$$aarticle
000005301 440_0 $$021027$$aCellular Physiology and Biochemistry$$v24$$x1015-8987$$y3
000005301 500__ $$aThe authors thank S. Wilms, S. Krause and A. Borner for excellent technical assistance. This project was supported by the Deutsche Forschungsgemeinschaft through the Sonderforschungsbereich 575 "Experimental Hepatology" (project C5).
000005301 520__ $$aHepatic encephalopathy (HE) in chronic liver disease is characterized by neuropsychiatric and motor disturbances and associated with a net increase of inhibitory neurotransmission. Though many studies, mostly carried out in animal models, have linked dysfunctions of single neurotransmitter systems with the pathogenesis of HE, reports concerning neurotransmitter receptor alterations are controversial. Little is known about the situation in humans. We carried out a multireceptor assessment of HE-associated changes in neurotransmitter receptor densities and affinities in human post-mortem brain samples. Dissociation constants and densities of different binding sites for glutamate, GABA, acetylcholine, norepinephrine, serotonin, dopamine and adenosine were determined by in vitro binding assays and quantitative receptor autoradiography in the motor cortex and putamen of HE and control brains. HE cases do not build a homogeneous group, but differ concerning direction and intensity of binding site density divergences from control values. The acetylcholine M2 binding site dissociation constant was significantly higher in HE brains. Nicotinic acetylcholine and adenosine type 1 and 2A densities were significantly down-regulated in the putamen of HE brains. Our data suggest that neurotransmitter alterations are probably not the primary key factor responsible for the neuropsychiatric and motor disturbances associated with HE.
000005301 536__ $$0G:(DE-Juel1)FUEK409$$2G:(DE-HGF)$$aFunktion und Dysfunktion des Nervensystems$$cP33$$x0
000005301 588__ $$aDataset connected to Web of Science, Pubmed
000005301 650_2 $$2MeSH$$aAcetylcholine: metabolism
000005301 650_2 $$2MeSH$$aAdenosine: metabolism
000005301 650_2 $$2MeSH$$aAdult
000005301 650_2 $$2MeSH$$aAged
000005301 650_2 $$2MeSH$$aAutoradiography
000005301 650_2 $$2MeSH$$aBasal Ganglia: physiopathology
000005301 650_2 $$2MeSH$$aBinding Sites
000005301 650_2 $$2MeSH$$aCase-Control Studies
000005301 650_2 $$2MeSH$$aDopamine: metabolism
000005301 650_2 $$2MeSH$$aFatal Outcome
000005301 650_2 $$2MeSH$$aFemale
000005301 650_2 $$2MeSH$$aGlutamic Acid: metabolism
000005301 650_2 $$2MeSH$$aHepatic Encephalopathy: physiopathology
000005301 650_2 $$2MeSH$$aHumans
000005301 650_2 $$2MeSH$$aLiver Cirrhosis: metabolism
000005301 650_2 $$2MeSH$$aLiver Cirrhosis, Alcoholic: metabolism
000005301 650_2 $$2MeSH$$aMale
000005301 650_2 $$2MeSH$$aMiddle Aged
000005301 650_2 $$2MeSH$$aMotor Cortex: metabolism
000005301 650_2 $$2MeSH$$aMotor Cortex: physiopathology
000005301 650_2 $$2MeSH$$aNorepinephrine: metabolism
000005301 650_2 $$2MeSH$$aProtein Binding
000005301 650_2 $$2MeSH$$aReceptors, Neurotransmitter: metabolism
000005301 650_2 $$2MeSH$$aSerotonin: metabolism
000005301 650_2 $$2MeSH$$agamma-Aminobutyric Acid: metabolism
000005301 650_7 $$00$$2NLM Chemicals$$aReceptors, Neurotransmitter
000005301 650_7 $$050-67-9$$2NLM Chemicals$$aSerotonin
000005301 650_7 $$051-41-2$$2NLM Chemicals$$aNorepinephrine
000005301 650_7 $$051-84-3$$2NLM Chemicals$$aAcetylcholine
000005301 650_7 $$056-12-2$$2NLM Chemicals$$agamma-Aminobutyric Acid
000005301 650_7 $$056-86-0$$2NLM Chemicals$$aGlutamic Acid
000005301 650_7 $$058-61-7$$2NLM Chemicals$$aAdenosine
000005301 650_7 $$2WoSType$$aJ
000005301 65320 $$2Author$$aHuman post-mortem brain tissue
000005301 65320 $$2Author$$aNeurotransmitter receptors
000005301 65320 $$2Author$$aAcetylcholine
000005301 65320 $$2Author$$aAdenosine
000005301 65320 $$2Author$$aPutamen
000005301 7001_ $$0P:(DE-HGF)0$$aBidmon, H.-J.$$b1
000005301 7001_ $$0P:(DE-Juel1)VDB21539$$aCremer, M.$$b2$$uFZJ
000005301 7001_ $$0P:(DE-HGF)0$$aSchleicher, A.$$b3
000005301 7001_ $$0P:(DE-HGF)0$$aKircheis, G.$$b4
000005301 7001_ $$0P:(DE-HGF)0$$aReifenberger, G.$$b5
000005301 7001_ $$0P:(DE-HGF)0$$aKostopoulos, G.$$b6
000005301 7001_ $$0P:(DE-HGF)0$$aHäussinger, D.$$b7
000005301 7001_ $$0P:(DE-Juel1)131714$$aZilles, K.$$b8$$uFZJ
000005301 773__ $$0PERI:(DE-600)1482056-0$$a10.1159/000233254$$gVol. 24$$q24$$tCellular physiology and biochemistry$$v24$$x1015-8987$$y2009
000005301 8567_ $$uhttp://dx.doi.org/10.1159/000233254
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