TY  - JOUR
AU  - Herzog, H.
AU  - Qaim, S. M.
AU  - Tellmann, L.
AU  - Spellerberg, S.
AU  - Kruecker, D.
AU  - Coenen, H. H.
TI  - Assessment of the short-lived non-pure positron-emitting nuclide 120I for PET imaging
JO  - European Journal of Nuclear Medicine and Molecular Imaging
VL  - 33
SN  - 1619-7070
CY  - Heidelberg [u.a.]
PB  - Springer-Verl.
M1  - PreJuSER-53143
SP  - 1249 - 1257
PY  - 2006
N1  - Record converted from VDB: 12.11.2012
AB  - The non-pure positron-emitting iodine isotope (120)I (T(1/2)=81 min) is a short-lived alternative to (124)I. (120)I has a positron abundance more than twice that of (124)I and a maximum positron energy of 4 MeV. This study was undertaken to evaluate and characterise the qualitative and quantitative PET imaging of (120)I.(120)I was produced via the (120)Te(p,n) reaction on highly enriched (120)Te. The measurements were done with the Siemens scanner HR+ and the 2D PET scanner GE PC4096+. A cylinder containing three cold inserts and a phantom resembling a human brain slice were used to evaluate half-life, positron abundance and background correction. To analyse the image resolution, a -mm tube placed in water was filled with (120)I and (18)F. Comparisons with (18)F, (124)I and (123)I (measured with SPECT) were made using the Hoffman 3D brain phantom.The half-life of 81.1 min was reproduced by the PET measurements. The PET-based positron abundance ranged from 47.9% to 55.0%. The reconstructed image resolution found with the HR+ was 5.4 mm FWHM (12.3 mm FWTM), in contrast to 4.6 mm (8.6 mm) when using (18)F. Erroneous positive and negative numbers of radioactivity found in the cold inserts became nearly zero when the background of gamma-coincidences was corrected for. Images of the Hoffman phantom were inferior to those obtained when (18)F or (124)I was applied but superior to the (123)I-SPECT images.Our data show that (120)I of high radionuclidic purity can be regarded as a suitable nuclide for the PET imaging of radioiodine-labelled pharmaceuticals.
KW  - Brain: radionuclide imaging
KW  - Humans
KW  - Image Enhancement: methods
KW  - Image Interpretation, Computer-Assisted: methods
KW  - Iodine Radioisotopes: chemistry
KW  - Iodine Radioisotopes: diagnostic use
KW  - Isotope Labeling: methods
KW  - Phantoms, Imaging
KW  - Positron-Emission Tomography: methods
KW  - Radiopharmaceuticals: chemical synthesis
KW  - Radiopharmaceuticals: diagnostic use
KW  - Reproducibility of Results
KW  - Sensitivity and Specificity
KW  - Iodine Radioisotopes (NLM Chemicals)
KW  - Radiopharmaceuticals (NLM Chemicals)
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
C6  - pmid:16845512
UR  - <Go to ISI:>//WOS:000241522600002
DO  - DOI:10.1007/s00259-006-0176-5
UR  - https://juser.fz-juelich.de/record/53143
ER  -