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@ARTICLE{Herzog:53143,
      author       = {Herzog, H. and Qaim, S. M. and Tellmann, L. and
                      Spellerberg, S. and Kruecker, D. and Coenen, H. H.},
      title        = {{A}ssessment of the short-lived non-pure positron-emitting
                      nuclide 120{I} for {PET} imaging},
      journal      = {European Journal of Nuclear Medicine and Molecular Imaging},
      volume       = {33},
      issn         = {1619-7070},
      address      = {Heidelberg [u.a.]},
      publisher    = {Springer-Verl.},
      reportid     = {PreJuSER-53143},
      pages        = {1249 - 1257},
      year         = {2006},
      note         = {Record converted from VDB: 12.11.2012},
      abstract     = {The non-pure positron-emitting iodine isotope (120)I
                      (T(1/2)=81 min) is a short-lived alternative to (124)I.
                      (120)I has a positron abundance more than twice that of
                      (124)I and a maximum positron energy of 4 MeV. This study
                      was undertaken to evaluate and characterise the qualitative
                      and quantitative PET imaging of (120)I.(120)I was produced
                      via the (120)Te(p,n) reaction on highly enriched (120)Te.
                      The measurements were done with the Siemens scanner HR+ and
                      the 2D PET scanner GE PC4096+. A cylinder containing three
                      cold inserts and a phantom resembling a human brain slice
                      were used to evaluate half-life, positron abundance and
                      background correction. To analyse the image resolution, a
                      -mm tube placed in water was filled with (120)I and (18)F.
                      Comparisons with (18)F, (124)I and (123)I (measured with
                      SPECT) were made using the Hoffman 3D brain phantom.The
                      half-life of 81.1 min was reproduced by the PET
                      measurements. The PET-based positron abundance ranged from
                      $47.9\%$ to $55.0\%.$ The reconstructed image resolution
                      found with the HR+ was 5.4 mm FWHM (12.3 mm FWTM), in
                      contrast to 4.6 mm (8.6 mm) when using (18)F. Erroneous
                      positive and negative numbers of radioactivity found in the
                      cold inserts became nearly zero when the background of
                      gamma-coincidences was corrected for. Images of the Hoffman
                      phantom were inferior to those obtained when (18)F or (124)I
                      was applied but superior to the (123)I-SPECT images.Our data
                      show that (120)I of high radionuclidic purity can be
                      regarded as a suitable nuclide for the PET imaging of
                      radioiodine-labelled pharmaceuticals.},
      keywords     = {Brain: radionuclide imaging / Humans / Image Enhancement:
                      methods / Image Interpretation, Computer-Assisted: methods /
                      Iodine Radioisotopes: chemistry / Iodine Radioisotopes:
                      diagnostic use / Isotope Labeling: methods / Phantoms,
                      Imaging / Positron-Emission Tomography: methods /
                      Radiopharmaceuticals: chemical synthesis /
                      Radiopharmaceuticals: diagnostic use / Reproducibility of
                      Results / Sensitivity and Specificity / Iodine Radioisotopes
                      (NLM Chemicals) / Radiopharmaceuticals (NLM Chemicals) / J
                      (WoSType)},
      cin          = {IME / INC},
      ddc          = {610},
      cid          = {I:(DE-Juel1)VDB54 / I:(DE-Juel1)VDB53},
      pnm          = {Funktion und Dysfunktion des Nervensystems},
      pid          = {G:(DE-Juel1)FUEK409},
      shelfmark    = {Radiology, Nuclear Medicine $\&$ Medical Imaging},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:16845512},
      UT           = {WOS:000241522600002},
      doi          = {10.1007/s00259-006-0176-5},
      url          = {https://juser.fz-juelich.de/record/53143},
}