Home > Publications database > Assessment of the short-lived non-pure positron-emitting nuclide 120I for PET imaging > print

001     53143
005     20180211174126.0
024 7 _ |2 pmid
|a pmid:16845512
024 7 _ |2 DOI
|a 10.1007/s00259-006-0176-5
024 7 _ |2 WOS
|a WOS:000241522600002
024 7 _ |2 ISSN
|a 1432-105X
037 _ _ |a PreJuSER-53143
041 _ _ |a eng
082 _ _ |a 610
084 _ _ |2 WoS
|a Radiology, Nuclear Medicine & Medical Imaging
100 1 _ |a Herzog, H.
|b 0
|u FZJ
|0 P:(DE-Juel1)VDB612
245 _ _ |a Assessment of the short-lived non-pure positron-emitting nuclide 120I for PET imaging
260 _ _ |c 2006
|a Heidelberg [u.a.]
|b Springer-Verl.
300 _ _ |a 1249 - 1257
336 7 _ |a Journal Article
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336 7 _ |a Output Types/Journal article
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336 7 _ |a Journal Article
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336 7 _ |a article
|2 DRIVER
440 _ 0 |a European Journal of Nuclear Medicine and Molecular Imaging
|x 1619-7070
|0 9906
|y 11
|v 33
500 _ _ |a Record converted from VDB: 12.11.2012
520 _ _ |a The non-pure positron-emitting iodine isotope (120)I (T(1/2)=81 min) is a short-lived alternative to (124)I. (120)I has a positron abundance more than twice that of (124)I and a maximum positron energy of 4 MeV. This study was undertaken to evaluate and characterise the qualitative and quantitative PET imaging of (120)I.(120)I was produced via the (120)Te(p,n) reaction on highly enriched (120)Te. The measurements were done with the Siemens scanner HR+ and the 2D PET scanner GE PC4096+. A cylinder containing three cold inserts and a phantom resembling a human brain slice were used to evaluate half-life, positron abundance and background correction. To analyse the image resolution, a -mm tube placed in water was filled with (120)I and (18)F. Comparisons with (18)F, (124)I and (123)I (measured with SPECT) were made using the Hoffman 3D brain phantom.The half-life of 81.1 min was reproduced by the PET measurements. The PET-based positron abundance ranged from 47.9% to 55.0%. The reconstructed image resolution found with the HR+ was 5.4 mm FWHM (12.3 mm FWTM), in contrast to 4.6 mm (8.6 mm) when using (18)F. Erroneous positive and negative numbers of radioactivity found in the cold inserts became nearly zero when the background of gamma-coincidences was corrected for. Images of the Hoffman phantom were inferior to those obtained when (18)F or (124)I was applied but superior to the (123)I-SPECT images.Our data show that (120)I of high radionuclidic purity can be regarded as a suitable nuclide for the PET imaging of radioiodine-labelled pharmaceuticals.
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588 _ _ |a Dataset connected to Web of Science, Pubmed
650 _ 2 |2 MeSH
|a Brain: radionuclide imaging
650 _ 2 |2 MeSH
|a Humans
650 _ 2 |2 MeSH
|a Image Enhancement: methods
650 _ 2 |2 MeSH
|a Image Interpretation, Computer-Assisted: methods
650 _ 2 |2 MeSH
|a Iodine Radioisotopes: chemistry
650 _ 2 |2 MeSH
|a Iodine Radioisotopes: diagnostic use
650 _ 2 |2 MeSH
|a Isotope Labeling: methods
650 _ 2 |2 MeSH
|a Phantoms, Imaging
650 _ 2 |2 MeSH
|a Positron-Emission Tomography: methods
650 _ 2 |2 MeSH
|a Radiopharmaceuticals: chemical synthesis
650 _ 2 |2 MeSH
|a Radiopharmaceuticals: diagnostic use
650 _ 2 |2 MeSH
|a Reproducibility of Results
650 _ 2 |2 MeSH
|a Sensitivity and Specificity
650 _ 7 |0 0
|2 NLM Chemicals
|a Iodine Radioisotopes
650 _ 7 |0 0
|2 NLM Chemicals
|a Radiopharmaceuticals
650 _ 7 |a J
|2 WoSType
653 2 0 |2 Author
|a iodine
653 2 0 |2 Author
|a PET
653 2 0 |2 Author
|a reconstruction quantification
700 1 _ |a Qaim, S. M.
|b 1
|u FZJ
|0 P:(DE-Juel1)VDB1300
700 1 _ |a Tellmann, L.
|b 2
|u FZJ
|0 P:(DE-Juel1)131797
700 1 _ |a Spellerberg, S.
|b 3
|u FZJ
|0 P:(DE-Juel1)VDB1552
700 1 _ |a Kruecker, D.
|b 4
|0 P:(DE-HGF)0
700 1 _ |a Coenen, H. H.
|b 5
|u FZJ
|0 P:(DE-Juel1)131816
773 _ _ |0 PERI:(DE-600)2098375-X
|a 10.1007/s00259-006-0176-5
|g Vol. 33, p. 1249 - 1257
|p 1249 - 1257
|q 33<1249 - 1257
|t European Journal of Nuclear Medicine and Molecular Imaging
|v 33
|x 1619-7070
|y 2006
856 7 _ |u http://dx.doi.org/10.1007/s00259-006-0176-5
909 C O |o oai:juser.fz-juelich.de:53143
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