%0 Journal Article
%A Meier, R. J.
%A Csiszár, A.
%A Klumpp, E.
%T Detecting the effect of very low amounts of penetrants in lipid bilayers using Raman spectroscopy
%J The journal of physical chemistry  / B
%V 110
%@ 1520-6106
%C Washington, DC
%I Soc.
%M PreJuSER-53548
%P 20727 - 20728
%D 2006
%Z Record converted from VDB: 12.11.2012
%X We show that, by the influence on the gauche content in the acyl chains, the effect of very low concentrations (order 10(-2) %) of penetrants (here 2,4-dichlorophenol) in lipid bilayers (here dipalmitoyl-glycerophosphatidylcholine) can be experimentally seen in the Raman spectra. The observed effects suggest increased order and are in accordance with previous X-ray diffraction and calorimetric data. These findings show great promise for studying in situ the effect of low amounts of various small molecules on cell membranes using Raman spectroscopy.
%K 1,2-Dipalmitoylphosphatidylcholine
%K Lipid Bilayers: metabolism
%K Organic Chemicals: pharmacokinetics
%K Permeability: drug effects
%K Phase Transition: drug effects
%K Spectrum Analysis, Raman
%K Lipid Bilayers (NLM Chemicals)
%K Organic Chemicals (NLM Chemicals)
%K 1,2-Dipalmitoylphosphatidylcholine (NLM Chemicals)
%K J (WoSType)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:17048874
%U <Go to ISI:>//WOS:000241381600001
%R 10.1021/jp0615757
%U https://juser.fz-juelich.de/record/53548