TY  - JOUR
AU  - Meier, R. J.
AU  - Csiszár, A.
AU  - Klumpp, E.
TI  - Detecting the effect of very low amounts of penetrants in lipid bilayers using Raman spectroscopy
JO  - The journal of physical chemistry  / B
VL  - 110
SN  - 1520-6106
CY  - Washington, DC
PB  - Soc.
M1  - PreJuSER-53548
SP  - 20727 - 20728
PY  - 2006
N1  - Record converted from VDB: 12.11.2012
AB  - We show that, by the influence on the gauche content in the acyl chains, the effect of very low concentrations (order 10(-2) %) of penetrants (here 2,4-dichlorophenol) in lipid bilayers (here dipalmitoyl-glycerophosphatidylcholine) can be experimentally seen in the Raman spectra. The observed effects suggest increased order and are in accordance with previous X-ray diffraction and calorimetric data. These findings show great promise for studying in situ the effect of low amounts of various small molecules on cell membranes using Raman spectroscopy.
KW  - 1,2-Dipalmitoylphosphatidylcholine
KW  - Lipid Bilayers: metabolism
KW  - Organic Chemicals: pharmacokinetics
KW  - Permeability: drug effects
KW  - Phase Transition: drug effects
KW  - Spectrum Analysis, Raman
KW  - Lipid Bilayers (NLM Chemicals)
KW  - Organic Chemicals (NLM Chemicals)
KW  - 1,2-Dipalmitoylphosphatidylcholine (NLM Chemicals)
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
C6  - pmid:17048874
UR  - <Go to ISI:>//WOS:000241381600001
DO  - DOI:10.1021/jp0615757
UR  - https://juser.fz-juelich.de/record/53548
ER  -