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@ARTICLE{Salber:53914,
      author       = {Salber, D. and Stoffels, G. and Pauleit, D. and
                      Reifenberger, G. and Sabel, M. and Shah, J. N. and Hamacher,
                      K. and Coenen, H. H. and Langen, K. J.},
      title        = {{D}ifferential uptake of [(18){F}]{FET} and
                      [(3){H}]l-methionine in focal cortical ischemia},
      journal      = {Nuclear medicine and biology},
      volume       = {33},
      issn         = {1872-9614},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {PreJuSER-53914},
      pages        = {1029 - 1035},
      year         = {2006},
      note         = {Record converted from VDB: 12.11.2012},
      abstract     = {Amino acids such as [(11)C-methyl]l-methionine are
                      particularly useful in brain tumor diagnosis, but unspecific
                      uptake (e.g., in cerebral ischemia) has been reported.
                      O-(2-[(18)F]fluoroethyl)-l-tyrosine ([(18)F]FET) shows a
                      clinical potential similar to that of l-methionine (MET) in
                      brain tumor diagnosis but is applicable on a wider clinical
                      scale. The aim of this study was to evaluate the uptake of
                      [(18)F]FET and [(3)H]MET in focal cortical ischemia in rats
                      by dual-tracer autoradiography.Focal cortical ischemia was
                      induced in 25 CDF rats using the photothrombosis (PT) model.
                      At different time points up to 6 weeks after the induction
                      of PT, [(18)F]FET and [(3)H]MET were injected intravenously.
                      Additionally, contrast-enhanced magnetic resonance imaging
                      (MRI) was performed in 10 animals. One hour after tracer
                      injection, brains were cut in coronal sections and evaluated
                      by dual-tracer autoradiography. Lesion-to-brain (L/B) ratios
                      were calculated by dividing the maximal uptake in the lesion
                      by the mean uptake in the brain. An L/B ratio of >2.0 was
                      considered indicative of pathological uptake. Histological
                      slices were stained by cresyl violet and supplemented by
                      immunostainings for glial fibrillary acidic protein (GFAP)
                      and CD68 in selected cases.A variably increased uptake of
                      both tracers was observed in the PT lesion and its
                      demarcation zone up to 7 days after PT for [(18)F]FET and up
                      to 6 weeks for [(3)H]MET. The cutoff level of 2.0 was
                      exceeded in 12/25 animals for [(18)F]FET and in 18/25
                      animals for [(3)H]MET. Focally increased tracer uptake
                      matched contrast enhancement in MRI in 3/10 cases for
                      [(18)F]FET and in 5/10 cases for [(3)H]MET.
                      Immunohistochemical staining in lesions with differential
                      uptake of [(18)F]FET and [(3)H]MET revealed that selective
                      uptake of [(18)F]FET was associated with GFAP-positive
                      astrogliosis while selective [(3)H]MET uptake correlated
                      with CD68-positive macrophage infiltration.[(18)F]FET, like
                      [(3)H]MET, may exhibit significant uptake in the periphery
                      of cortical infarctions, which has to be considered in the
                      differential diagnosis of unknown brain lesions. There are
                      discrepancies between [(18)F]FET and [(3)H]MET uptake in the
                      area of infarctions that appear to be caused by the
                      preferential uptake of [(18)F]FET in reactive astrocytes
                      versus the preferential uptake of [(3)H]MET in macrophages.},
      keywords     = {Animals / Brain Ischemia: metabolism / Cerebral Cortex:
                      blood supply / Fluorine Radioisotopes: diagnostic use / Male
                      / Methionine: pharmacokinetics / Radiopharmaceuticals:
                      pharmacokinetics / Rats / Rats, Inbred F344 / Tritium:
                      diagnostic use / Tyrosine: analogs $\&$ derivatives /
                      Tyrosine: pharmacokinetics / Fluorine Radioisotopes (NLM
                      Chemicals) / O-(2-fluoroethyl)tyrosine (NLM Chemicals) /
                      Radiopharmaceuticals (NLM Chemicals) / Tritium (NLM
                      Chemicals) / Tyrosine (NLM Chemicals) / Methionine (NLM
                      Chemicals) / J (WoSType)},
      cin          = {IME / INC / JARA-BRAIN},
      ddc          = {610},
      cid          = {I:(DE-Juel1)VDB54 / I:(DE-Juel1)VDB53 /
                      $I:(DE-82)080010_20140620$},
      pnm          = {Funktion und Dysfunktion des Nervensystems},
      pid          = {G:(DE-Juel1)FUEK409},
      shelfmark    = {Radiology, Nuclear Medicine $\&$ Medical Imaging},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:17127177},
      UT           = {WOS:000242840500012},
      doi          = {10.1016/j.nucmedbio.2006.09.004},
      url          = {https://juser.fz-juelich.de/record/53914},
}