%0 Journal Article
%A Granzin, J.
%A Eckhoff, A.
%A Weiergräber, O. H.
%T Crystal structure of a multi-domain immunophilin from Arabidopsis thaliana: A paradigm for regulation of plan ABC transporters
%J Journal of molecular biology
%V 364
%@ 0022-2836
%C Amsterdam [u.a.]
%I Elsevier
%M PreJuSER-54327
%P 799 - 809
%D 2006
%Z Record converted from VDB: 12.11.2012
%X FKBP42 is a membrane-anchored immunophilin playing a critical role in morphogenesis and development of higher plants. We present the X-ray structure of the cytoplasmic portion of FKBP42 comprising both the FKBP-like domain and the TPR domain at 2.85 A resolution. The data shed light on the probable binding modes of key interaction partners, including HSP90 and two classes of ABC transporters. The resulting models provide a structural background for further investigation of the unique biological properties of this protein.
%K ATP-Binding Cassette Transporters: metabolism
%K Arabidopsis Proteins: chemistry
%K Crystallography, X-Ray
%K Cytoplasm
%K HSP90 Heat-Shock Proteins: metabolism
%K Immunophilins: chemistry
%K Molecular Structure
%K Protein Binding
%K Protein Conformation
%K Tacrolimus Binding Proteins: chemistry
%K ATP-Binding Cassette Transporters (NLM Chemicals)
%K Arabidopsis Proteins (NLM Chemicals)
%K HSP90 Heat-Shock Proteins (NLM Chemicals)
%K TWD1 protein, Arabidopsis (NLM Chemicals)
%K Tacrolimus Binding Proteins (NLM Chemicals)
%K Immunophilins (NLM Chemicals)
%K J (WoSType)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:17045295
%U <Go to ISI:>//WOS:000242674200019
%R 10.1016/j.jmb.2006.09.052
%U https://juser.fz-juelich.de/record/54327