TY  - JOUR
AU  - Granzin, J.
AU  - Eckhoff, A.
AU  - Weiergräber, O. H.
TI  - Crystal structure of a multi-domain immunophilin from Arabidopsis thaliana: A paradigm for regulation of plan ABC transporters
JO  - Journal of molecular biology
VL  - 364
SN  - 0022-2836
CY  - Amsterdam [u.a.]
PB  - Elsevier
M1  - PreJuSER-54327
SP  - 799 - 809
PY  - 2006
N1  - Record converted from VDB: 12.11.2012
AB  - FKBP42 is a membrane-anchored immunophilin playing a critical role in morphogenesis and development of higher plants. We present the X-ray structure of the cytoplasmic portion of FKBP42 comprising both the FKBP-like domain and the TPR domain at 2.85 A resolution. The data shed light on the probable binding modes of key interaction partners, including HSP90 and two classes of ABC transporters. The resulting models provide a structural background for further investigation of the unique biological properties of this protein.
KW  - ATP-Binding Cassette Transporters: metabolism
KW  - Arabidopsis Proteins: chemistry
KW  - Crystallography, X-Ray
KW  - Cytoplasm
KW  - HSP90 Heat-Shock Proteins: metabolism
KW  - Immunophilins: chemistry
KW  - Molecular Structure
KW  - Protein Binding
KW  - Protein Conformation
KW  - Tacrolimus Binding Proteins: chemistry
KW  - ATP-Binding Cassette Transporters (NLM Chemicals)
KW  - Arabidopsis Proteins (NLM Chemicals)
KW  - HSP90 Heat-Shock Proteins (NLM Chemicals)
KW  - TWD1 protein, Arabidopsis (NLM Chemicals)
KW  - Tacrolimus Binding Proteins (NLM Chemicals)
KW  - Immunophilins (NLM Chemicals)
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
C6  - pmid:17045295
UR  - <Go to ISI:>//WOS:000242674200019
DO  - DOI:10.1016/j.jmb.2006.09.052
UR  - https://juser.fz-juelich.de/record/54327
ER  -