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000005449 0247_ $$2DOI$$a10.1085/jgp.200910194
000005449 0247_ $$2WOS$$aWOS:000268367600003
000005449 037__ $$aPreJuSER-5449
000005449 041__ $$aeng
000005449 082__ $$a610
000005449 084__ $$2WoS$$aPhysiology
000005449 1001_ $$0P:(DE-HGF)0$$aMüller, J.$$b0
000005449 245__ $$aThe principal neurons of the medial nucleus of the trapezoid body and NG2+ glial cells receive coordinated excitatory synaptic input.
000005449 260__ $$aNew York, NY$$bRockefeller Univ. Press$$c2009
000005449 300__ $$a115 - 127
000005449 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
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000005449 440_0 $$09166$$aJournal of General Physiology$$v134$$x0022-1295$$y2
000005449 500__ $$aWe thank R. Juttner for discussions and comments on the manuscript and for sharing chemicals, K. Karram and J. Trotter for providing antibodies, and R. Krober for technical assistance.This study was supported by a grant from the Deutsche Forschungsgemeinschaft (SPP 1172).
000005449 520__ $$aGlial cell processes are part of the synaptic structure and sense spillover of transmitter, while some glial cells can even receive direct synaptic input. Here, we report that a defined type of glial cell in the medial nucleus of the trapezoid body (MNTB) receives excitatory glutamatergic synaptic input from the calyx of Held (CoH). This giant glutamatergic terminal forms an axosomatic synapse with a single principal neuron located in the MNTB. The NG2 glia, as postsynaptic principal neurons, establish synapse-like structures with the CoH terminal. In contrast to the principal neurons, which are known to receive excitatory as well as inhibitory inputs, the NG2 glia receive mostly, if not exclusively, alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid receptor-mediated evoked and spontaneous synaptic input. Simultaneous recordings from neurons and NG2 glia indicate that they partially receive synchronized spontaneous input. This shows that an NG2(+) glial cell and a postsynaptic neuron share presynaptic terminals.
000005449 536__ $$0G:(DE-Juel1)FUEK409$$2G:(DE-HGF)$$aFunktion und Dysfunktion des Nervensystems$$cP33$$x0
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000005449 650_2 $$2MeSH$$aAnimals
000005449 650_2 $$2MeSH$$aAstrocytes: metabolism
000005449 650_2 $$2MeSH$$aAuditory Pathways: physiology
000005449 650_2 $$2MeSH$$aBrain Stem: cytology
000005449 650_2 $$2MeSH$$aBrain Stem: physiology
000005449 650_2 $$2MeSH$$aGreen Fluorescent Proteins: genetics
000005449 650_2 $$2MeSH$$aGreen Fluorescent Proteins: metabolism
000005449 650_2 $$2MeSH$$aImmunohistochemistry
000005449 650_2 $$2MeSH$$aMice
000005449 650_2 $$2MeSH$$aMice, Transgenic
000005449 650_2 $$2MeSH$$aMicroscopy, Electron
000005449 650_2 $$2MeSH$$aNeuroglia: metabolism
000005449 650_2 $$2MeSH$$aNeurons: metabolism
000005449 650_2 $$2MeSH$$aReceptors, AMPA: metabolism
000005449 650_2 $$2MeSH$$aSignal Transduction
000005449 650_2 $$2MeSH$$aSynaptic Transmission: physiology
000005449 650_7 $$00$$2NLM Chemicals$$aReceptors, AMPA
000005449 650_7 $$0147336-22-9$$2NLM Chemicals$$aGreen Fluorescent Proteins
000005449 650_7 $$2WoSType$$aJ
000005449 7001_ $$0P:(DE-HGF)0$$aReyes-Haro, D.$$b1
000005449 7001_ $$0P:(DE-HGF)0$$aRivneva, T.$$b2
000005449 7001_ $$0P:(DE-HGF)0$$aNolte, C.$$b3
000005449 7001_ $$0P:(DE-HGF)0$$aSchaette, R.$$b4
000005449 7001_ $$0P:(DE-Juel1)VDB86960$$aLübke, J.H.R.$$b5$$uFZJ
000005449 7001_ $$0P:(DE-HGF)0$$aKettenmann, H.$$b6
000005449 773__ $$0PERI:(DE-600)1477246-2$$a10.1085/jgp.200910194$$gVol. 134, p. 115 - 127$$p115 - 127$$q134<115 - 127$$tThe @journal of general physiology$$v134$$x0022-1295$$y2009
000005449 8567_ $$2Pubmed Central$$uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2717692
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