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000054737 084__ $$2WoS$$aBiochemical Research Methods
000054737 084__ $$2WoS$$aChemistry, Medicinal
000054737 084__ $$2WoS$$aChemistry, Analytical
000054737 084__ $$2WoS$$aPharmacology & Pharmacy
000054737 1001_ $$0P:(DE-Juel1)VDB43841$$aOlma, S.$$b0$$uFZJ
000054737 245__ $$a4-[18F]fluorophenyl ureas via carbamate-4-nitrophenyl esters and 4-[18F]fluoroaniline
000054737 260__ $$aNew York, NY [u.a.]$$bWiley$$c2006
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000054737 440_0 $$03464$$aJournal of Labelled Compounds and Radiopharmaceuticals$$v49$$x0362-4803
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000054737 520__ $$aFour different no carrier added (n.c.a.) 4-[F-18]fluorophenylurea derivatives are synthesized as model compounds via two alternative routes. In both cases carbamate-4-nitrophenylesters are used as intermediates. Either n.c.a. 4-[F-18]fluoroaniline reacts with carbamates of several amines, or the carbamate of n.c.a. 4-[F-18]fluoroaniline is formed at first and an amine is added subsequently to yield the urea derivative. The choice of the appropriate way of reaction depends on the possibilities of precursor synthesis. The radiochemical yields reach up to 80% after 50min of synthesis time while no radiochemical by-products can be determined. These high yields were possible due to an optimized preparation of n.c.a. 4-[F-18]fluoroaniline with a radiochemical yield of up to 90%. From the various ways of its radiosynthesis, the substitution with n.c.a. [F-18]fluoride on dinitrobenzene is chosen, using phosphorous acid and palladium black for reduction of the second nitro group. (c) Copyright 2006 John Wiley & Sons, Ltd.
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000054737 65320 $$2Author$$an.c.a. radiofluorination
000054737 65320 $$2Author$$a[F-18]fluorophenyl ureas
000054737 65320 $$2Author$$a[F-18]fluoroaniline
000054737 65320 $$2Author$$acarbamates
000054737 650_7 $$2WoSType$$aJ
000054737 7001_ $$0P:(DE-Juel1)VDB6242$$aErmert, J.$$b1$$uFZJ
000054737 7001_ $$0P:(DE-Juel1)131816$$aCoenen, H. H.$$b2$$uFZJ
000054737 773__ $$0PERI:(DE-600)1491841-9$$a10.1002/jlcr.1121$$gVol. 49, p. 1037 - 1050$$n12$$p1037 - 1050$$q49<1037 - 1050$$tJournal of labelled compounds and radiopharmaceuticals$$v49$$x0362-4803$$y2006
000054737 8567_ $$uhttp://dx.doi.org/10.1002/jlcr.1121
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