TY  - JOUR
AU  - Olma, S.
AU  - Ermert, J.
AU  - Coenen, H. H.
TI  - 4-[18F]fluorophenyl ureas via carbamate-4-nitrophenyl esters and 4-[18F]fluoroaniline
JO  - Journal of labelled compounds and radiopharmaceuticals
VL  - 49
IS  - 12
SN  - 0362-4803
CY  - New York, NY [u.a.]
PB  - Wiley
M1  - PreJuSER-54737
SP  - 1037 - 1050
PY  - 2006
N1  - Record converted from VDB: 12.11.2012
AB  - Four different no carrier added (n.c.a.) 4-[F-18]fluorophenylurea derivatives are synthesized as model compounds via two alternative routes. In both cases carbamate-4-nitrophenylesters are used as intermediates. Either n.c.a. 4-[F-18]fluoroaniline reacts with carbamates of several amines, or the carbamate of n.c.a. 4-[F-18]fluoroaniline is formed at first and an amine is added subsequently to yield the urea derivative. The choice of the appropriate way of reaction depends on the possibilities of precursor synthesis. The radiochemical yields reach up to 80% after 50min of synthesis time while no radiochemical by-products can be determined. These high yields were possible due to an optimized preparation of n.c.a. 4-[F-18]fluoroaniline with a radiochemical yield of up to 90%. From the various ways of its radiosynthesis, the substitution with n.c.a. [F-18]fluoride on dinitrobenzene is chosen, using phosphorous acid and palladium black for reduction of the second nitro group. (c) Copyright 2006 John Wiley & Sons, Ltd.
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000242335900002
DO  - DOI:10.1002/jlcr.1121
UR  - https://juser.fz-juelich.de/record/54737
ER  -