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@ARTICLE{Olma:54737,
author = {Olma, S. and Ermert, J. and Coenen, H. H.},
title = {4-[18{F}]fluorophenyl ureas via carbamate-4-nitrophenyl
esters and 4-[18{F}]fluoroaniline},
journal = {Journal of labelled compounds and radiopharmaceuticals},
volume = {49},
number = {12},
issn = {0362-4803},
address = {New York, NY [u.a.]},
publisher = {Wiley},
reportid = {PreJuSER-54737},
pages = {1037 - 1050},
year = {2006},
note = {Record converted from VDB: 12.11.2012},
abstract = {Four different no carrier added (n.c.a.)
4-[F-18]fluorophenylurea derivatives are synthesized as
model compounds via two alternative routes. In both cases
carbamate-4-nitrophenylesters are used as intermediates.
Either n.c.a. 4-[F-18]fluoroaniline reacts with carbamates
of several amines, or the carbamate of n.c.a.
4-[F-18]fluoroaniline is formed at first and an amine is
added subsequently to yield the urea derivative. The choice
of the appropriate way of reaction depends on the
possibilities of precursor synthesis. The radiochemical
yields reach up to $80\%$ after 50min of synthesis time
while no radiochemical by-products can be determined. These
high yields were possible due to an optimized preparation of
n.c.a. 4-[F-18]fluoroaniline with a radiochemical yield of
up to $90\%.$ From the various ways of its radiosynthesis,
the substitution with n.c.a. [F-18]fluoride on
dinitrobenzene is chosen, using phosphorous acid and
palladium black for reduction of the second nitro group. (c)
Copyright 2006 John Wiley $\&$ Sons, Ltd.},
keywords = {J (WoSType)},
cin = {INC},
ddc = {540},
cid = {I:(DE-Juel1)VDB53},
pnm = {Funktion und Dysfunktion des Nervensystems},
pid = {G:(DE-Juel1)FUEK409},
shelfmark = {Biochemical Research Methods / Chemistry, Medicinal /
Chemistry, Analytical / Pharmacology $\&$ Pharmacy},
typ = {PUB:(DE-HGF)16},
UT = {WOS:000242335900002},
doi = {10.1002/jlcr.1121},
url = {https://juser.fz-juelich.de/record/54737},
}