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| 005 | 20200402210300.0 | ||
| 024 | 7 | _ | |2 pmid |a pmid:16328780 |
| 024 | 7 | _ | |2 DOI |a 10.1007/s11373-005-9043-9 |
| 024 | 7 | _ | |2 WOS |a WOS:000237502100001 |
| 024 | 7 | _ | |a altmetric:3679465 |2 altmetric |
| 037 | _ | _ | |a PreJuSER-55020 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 610 |
| 084 | _ | _ | |2 WoS |a Medicine, Research & Experimental |
| 100 | 1 | _ | |a Haenel, K. |b 0 |u FZJ |0 P:(DE-Juel1)VDB65446 |
| 245 | _ | _ | |a Solution structure of the X4 protein coded by the SARS related coronavirus reveals an immunoglobulin like fold and suggests a binding activity to integrin I domains |
| 260 | _ | _ | |a London |b BioMed Central |c 2006 |
| 300 | _ | _ | |a 281 - 293 |
| 336 | 7 | _ | |a Journal Article |0 PUB:(DE-HGF)16 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a article |2 DRIVER |
| 440 | _ | 0 | |a Journal of Biomedical Science |x 1021-7770 |0 14721 |v 13 |
| 500 | _ | _ | |a Record converted from VDB: 12.11.2012 |
| 520 | _ | _ | |a The SARS related Coronavirus genome contains a variety of novel accessory genes. One of these, called ORF7a or ORF8, code for a protein, known as 7a, U122 or X4. We set out to determine the three-dimensional structure of the soluble ectodomain of this type-I transmembrane protein by nuclear magnetic resonance spectroscopy. The fold of the protein is the first member of a further variation of the immunoglobulin like beta-sandwich fold. Because X4 does not reveal significant sequence homologies to proteins in the data bases, we carried out a structure based similarity search for proteins with known function. High structural similarity to Dl domains of ICAM-1 and ICAM-2, and common features in amino acid sequence between X4 and ICAM-1, suggest X4 to possess binding activity for the alpha(L) integrin I domain of LFA-1. Further, based on this structure based prediction, potential functions of X4 in virus replication and pathogenesis are discussed. |
| 536 | _ | _ | |a Funktion und Dysfunktion des Nervensystems |c P33 |2 G:(DE-HGF) |0 G:(DE-Juel1)FUEK409 |x 0 |
| 588 | _ | _ | |a Dataset connected to Web of Science, Pubmed |
| 650 | _ | 2 | |2 MeSH |a Amino Acid Sequence |
| 650 | _ | 2 | |2 MeSH |a Antigens, CD: chemistry |
| 650 | _ | 2 | |2 MeSH |a Cell Adhesion Molecules: chemistry |
| 650 | _ | 2 | |2 MeSH |a Cloning, Molecular |
| 650 | _ | 2 | |2 MeSH |a Humans |
| 650 | _ | 2 | |2 MeSH |a Immunoglobulins: chemistry |
| 650 | _ | 2 | |2 MeSH |a Integrins: chemistry |
| 650 | _ | 2 | |2 MeSH |a Intercellular Adhesion Molecule-1: chemistry |
| 650 | _ | 2 | |2 MeSH |a Interleukin-1: chemistry |
| 650 | _ | 2 | |2 MeSH |a Lymphocyte Function-Associated Antigen-1: chemistry |
| 650 | _ | 2 | |2 MeSH |a Models, Molecular |
| 650 | _ | 2 | |2 MeSH |a Molecular Sequence Data |
| 650 | _ | 2 | |2 MeSH |a Open Reading Frames |
| 650 | _ | 2 | |2 MeSH |a Protein Structure, Secondary |
| 650 | _ | 2 | |2 MeSH |a Protein Structure, Tertiary |
| 650 | _ | 2 | |2 MeSH |a SARS Virus: chemistry |
| 650 | _ | 2 | |2 MeSH |a Viral Matrix Proteins: chemistry |
| 650 | _ | 2 | |2 MeSH |a Viral Proteins: chemistry |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Antigens, CD |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Cell Adhesion Molecules |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Immunoglobulins |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Integrins |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Interleukin-1 |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Lymphocyte Function-Associated Antigen-1 |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Viral Matrix Proteins |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Viral Proteins |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a sars7a protein, SARS virus |
| 650 | _ | 7 | |0 126547-89-5 |2 NLM Chemicals |a Intercellular Adhesion Molecule-1 |
| 650 | _ | 7 | |0 NM_000873 |2 NLM Chemicals |a ICAM2 protein, human |
| 650 | _ | 7 | |a J |2 WoSType |
| 653 | 2 | 0 | |2 Author |a 7a |
| 653 | 2 | 0 | |2 Author |a coronavirus |
| 653 | 2 | 0 | |2 Author |a immunoglobulin fold |
| 653 | 2 | 0 | |2 Author |a integrin |
| 653 | 2 | 0 | |2 Author |a LFA-1 |
| 653 | 2 | 0 | |2 Author |a NMR structure determination |
| 653 | 2 | 0 | |2 Author |a ORF8 |
| 653 | 2 | 0 | |2 Author |a SARS |
| 653 | 2 | 0 | |2 Author |a U122 |
| 653 | 2 | 0 | |2 Author |a X4 |
| 700 | 1 | _ | |a Stangler, T. |b 1 |u FZJ |0 P:(DE-Juel1)VDB8627 |
| 700 | 1 | _ | |a Stoldt, M. |b 2 |u FZJ |0 P:(DE-Juel1)VDB21601 |
| 700 | 1 | _ | |a Willbold, D. |b 3 |u FZJ |0 P:(DE-Juel1)132029 |
| 773 | _ | _ | |a 10.1007/s11373-005-9043-9 |g Vol. 13, p. 281 - 293 |p 281 - 293 |q 13<281 - 293 |0 PERI:(DE-600)1482918-6 |t Journal of biomedical science |v 13 |y 2006 |x 1021-7770 |
| 856 | 7 | _ | |u http://dx.doi.org/10.1007/s11373-005-9043-9 |
| 909 | C | O | |o oai:juser.fz-juelich.de:55020 |p VDB |
| 913 | 1 | _ | |k P33 |v Funktion und Dysfunktion des Nervensystems |l Funktion und Dysfunktion des Nervensystems |b Gesundheit |0 G:(DE-Juel1)FUEK409 |x 0 |
| 914 | 1 | _ | |y 2006 |
| 915 | _ | _ | |0 StatID:(DE-HGF)0010 |a JCR/ISI refereed |
| 920 | 1 | _ | |k IBI-2 |l Biologische Strukturforschung |d 31.12.2006 |g IBI |0 I:(DE-Juel1)VDB58 |x 0 |
| 970 | _ | _ | |a VDB:(DE-Juel1)85879 |
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| 980 | _ | _ | |a I:(DE-Juel1)ISB-2-20090406 |
| 980 | _ | _ | |a UNRESTRICTED |
| 980 | _ | _ | |a I:(DE-Juel1)ICS-6-20110106 |
| 981 | _ | _ | |a I:(DE-Juel1)IBI-7-20200312 |
| 981 | _ | _ | |a I:(DE-Juel1)ISB-2-20090406 |
| 981 | _ | _ | |a I:(DE-Juel1)ICS-6-20110106 |
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